Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.
Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions u...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826264118665936896 |
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| author | Dumas, A Spicer, C Gao, Z Takehana, T Lin, Y Yasukohchi, T Davis, B |
| author_facet | Dumas, A Spicer, C Gao, Z Takehana, T Lin, Y Yasukohchi, T Davis, B |
| author_sort | Dumas, A |
| collection | OXFORD |
| description | Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| first_indexed | 2024-03-06T20:02:38Z |
| format | Journal article |
| id | oxford-uuid:27d6818c-17a5-4103-8825-4b7a90b38693 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:02:38Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:27d6818c-17a5-4103-8825-4b7a90b386932022-03-26T12:09:12ZSelf-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27d6818c-17a5-4103-8825-4b7a90b38693EnglishSymplectic Elements at Oxford2013Dumas, ASpicer, CGao, ZTakehana, TLin, YYasukohchi, TDavis, BBuilding with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| spellingShingle | Dumas, A Spicer, C Gao, Z Takehana, T Lin, Y Yasukohchi, T Davis, B Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title | Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title_full | Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title_fullStr | Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title_full_unstemmed | Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title_short | Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation. |
| title_sort | self liganded suzuki miyaura coupling for site selective protein pegylation |
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