Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flo...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797059339083579392 |
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| author | Lee, J Shirodaria, C Jackson, C Robson, M Antoniades, C Francis, J Wiesmann, F Channon, K Neubauer, S Choudhury, R |
| author_facet | Lee, J Shirodaria, C Jackson, C Robson, M Antoniades, C Francis, J Wiesmann, F Channon, K Neubauer, S Choudhury, R |
| author_sort | Lee, J |
| collection | OXFORD |
| description | Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy. |
| first_indexed | 2024-03-06T20:02:48Z |
| format | Journal article |
| id | oxford-uuid:27e522cf-6313-473c-86f9-d2ec058cdfff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:02:48Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:27e522cf-6313-473c-86f9-d2ec058cdfff2022-03-26T12:09:33ZMulti-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27e522cf-6313-473c-86f9-d2ec058cdfffEnglishSymplectic Elements at Oxford2007Lee, JShirodaria, CJackson, CRobson, MAntoniades, CFrancis, JWiesmann, FChannon, KNeubauer, SChoudhury, RVascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy. |
| spellingShingle | Lee, J Shirodaria, C Jackson, C Robson, M Antoniades, C Francis, J Wiesmann, F Channon, K Neubauer, S Choudhury, R Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title | Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title_full | Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title_fullStr | Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title_full_unstemmed | Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title_short | Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. |
| title_sort | multi modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus |
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