Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study
<p><strong>Background</strong> Few studies have investigated congenital anomalies in relation to municipal waste incinerators (MWIs) and results are inconclusive.</p> <p><strong>Objectives</strong> To conduct a national investigation into the risk of congeni...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2019
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| _version_ | 1797059339922440192 |
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| author | Parkes, B Hansell, A Ghosh, R Douglas, P Fecht, D Wellesley, D Kurinczuk, J Rankin, J De Hoogh, K Fuller, G Elliott, P Toledano, M |
| author_facet | Parkes, B Hansell, A Ghosh, R Douglas, P Fecht, D Wellesley, D Kurinczuk, J Rankin, J De Hoogh, K Fuller, G Elliott, P Toledano, M |
| author_sort | Parkes, B |
| collection | OXFORD |
| description | <p><strong>Background</strong> Few studies have investigated congenital anomalies in relation to municipal waste incinerators (MWIs) and results are inconclusive.</p> <p><strong>Objectives</strong> To conduct a national investigation into the risk of congenital anomalies in babies born to mothers living within 10 km of an MWI associated with: i) modelled concentrations of PM<sub>10</sub> as a proxy for MWI emissions more generally and; ii) proximity of residential postcode to nearest MWI, in areas in England and Scotland that are covered by a congenital anomaly register.</p> <p><strong>Methods</strong> Retrospective population-based cohort study within 10 km of 10 MWIs in England and Scotland operating between 2003 and 2010. Exposure was proximity to MWI and log of daily mean modelled ground-level particulate matter ≤10 μm diameter (PM<sub>10</sub>) concentrations.</p> <p><strong>Results</strong> Analysis included 219,486 births, stillbirths and terminations of pregnancy for fetal anomaly of which 5154 were cases of congenital anomalies. Fully adjusted odds ratio (OR) per doubling in PM<sub>10</sub> was: 1·00 (95% CI 0·98–1·02) for all congenital anomalies; 0·99 (0·97–1·01) for all congenital anomalies excluding chromosomal anomalies. For every 1 km closer to an MWI adjusted OR was: 1·02 (1·00–1·04) for all congenital anomalies combined; 1·02 (1·00–1·04) for all congenital anomalies excluding chromosomal anomalies; and, for specific anomaly groups, 1·04 (1·01–1·08) for congenital heart defect sand 1·07 (1·02–1·12) for genital anomalies.</p> <p><strong>Discussion</strong> We found no increased risk of congenital anomalies in relation to modelled PM<sub>10</sub> emissions, but there were small excess risks associated with congenital heart defects and genital anomalies in proximity to MWIs. These latter findings may well reflect incomplete control for confounding, but a possible causal effect cannot be excluded.</p> |
| first_indexed | 2024-03-06T20:02:49Z |
| format | Journal article |
| id | oxford-uuid:27e6859b-a153-452d-b486-36c68426e6f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:02:49Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:27e6859b-a153-452d-b486-36c68426e6f22022-03-26T12:09:36ZRisk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27e6859b-a153-452d-b486-36c68426e6f2EnglishSymplectic Elements at OxfordElsevier2019Parkes, BHansell, AGhosh, RDouglas, PFecht, DWellesley, DKurinczuk, JRankin, JDe Hoogh, KFuller, GElliott, PToledano, M<p><strong>Background</strong> Few studies have investigated congenital anomalies in relation to municipal waste incinerators (MWIs) and results are inconclusive.</p> <p><strong>Objectives</strong> To conduct a national investigation into the risk of congenital anomalies in babies born to mothers living within 10 km of an MWI associated with: i) modelled concentrations of PM<sub>10</sub> as a proxy for MWI emissions more generally and; ii) proximity of residential postcode to nearest MWI, in areas in England and Scotland that are covered by a congenital anomaly register.</p> <p><strong>Methods</strong> Retrospective population-based cohort study within 10 km of 10 MWIs in England and Scotland operating between 2003 and 2010. Exposure was proximity to MWI and log of daily mean modelled ground-level particulate matter ≤10 μm diameter (PM<sub>10</sub>) concentrations.</p> <p><strong>Results</strong> Analysis included 219,486 births, stillbirths and terminations of pregnancy for fetal anomaly of which 5154 were cases of congenital anomalies. Fully adjusted odds ratio (OR) per doubling in PM<sub>10</sub> was: 1·00 (95% CI 0·98–1·02) for all congenital anomalies; 0·99 (0·97–1·01) for all congenital anomalies excluding chromosomal anomalies. For every 1 km closer to an MWI adjusted OR was: 1·02 (1·00–1·04) for all congenital anomalies combined; 1·02 (1·00–1·04) for all congenital anomalies excluding chromosomal anomalies; and, for specific anomaly groups, 1·04 (1·01–1·08) for congenital heart defect sand 1·07 (1·02–1·12) for genital anomalies.</p> <p><strong>Discussion</strong> We found no increased risk of congenital anomalies in relation to modelled PM<sub>10</sub> emissions, but there were small excess risks associated with congenital heart defects and genital anomalies in proximity to MWIs. These latter findings may well reflect incomplete control for confounding, but a possible causal effect cannot be excluded.</p> |
| spellingShingle | Parkes, B Hansell, A Ghosh, R Douglas, P Fecht, D Wellesley, D Kurinczuk, J Rankin, J De Hoogh, K Fuller, G Elliott, P Toledano, M Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title | Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title_full | Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title_fullStr | Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title_full_unstemmed | Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title_short | Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study |
| title_sort | risk of congenital anomalies near municipal waste incinerators in england and scotland retrospective population based cohort study |
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