Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission.

Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur...

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Main Authors: Raimondo, J, Kay, L, Ellender, T, Akerman, C
格式: Journal article
语言:English
出版: 2012