Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.
Human endogenous retroviruses (HERVs) constitute 8% of the human genome and have been implicated in both health and disease. Increased HERV gene activity occurs in immunologically activated glia, although the consequences of HERV expression in the nervous system remain uncertain. Here, we report tha...
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2004
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| _version_ | 1826264168416673792 |
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| author | Antony, J van Marle, G Opii, W Butterfield, D Mallet, F Yong, V Wallace, J Deacon, R Warren, K Power, C |
| author_facet | Antony, J van Marle, G Opii, W Butterfield, D Mallet, F Yong, V Wallace, J Deacon, R Warren, K Power, C |
| author_sort | Antony, J |
| collection | OXFORD |
| description | Human endogenous retroviruses (HERVs) constitute 8% of the human genome and have been implicated in both health and disease. Increased HERV gene activity occurs in immunologically activated glia, although the consequences of HERV expression in the nervous system remain uncertain. Here, we report that the HERV-W encoded glycoprotein syncytin is upregulated in glial cells within acute demyelinating lesions of multiple sclerosis patients. Syncytin expression in astrocytes induced the release of redox reactants, which were cytotoxic to oligodendrocytes. Syncytin-mediated neuroinflammation and death of oligodendrocytes, with the ensuing neurobehavioral deficits, were prevented by the antioxidant ferulic acid in a mouse model of multiple sclerosis. Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention. |
| first_indexed | 2024-03-06T20:03:24Z |
| format | Journal article |
| id | oxford-uuid:281a09c6-a504-4cff-bb85-4f6bd7d2b162 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:03:24Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:281a09c6-a504-4cff-bb85-4f6bd7d2b1622022-03-26T12:11:07ZHuman endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:281a09c6-a504-4cff-bb85-4f6bd7d2b162EnglishSymplectic Elements at Oxford2004Antony, Jvan Marle, GOpii, WButterfield, DMallet, FYong, VWallace, JDeacon, RWarren, KPower, CHuman endogenous retroviruses (HERVs) constitute 8% of the human genome and have been implicated in both health and disease. Increased HERV gene activity occurs in immunologically activated glia, although the consequences of HERV expression in the nervous system remain uncertain. Here, we report that the HERV-W encoded glycoprotein syncytin is upregulated in glial cells within acute demyelinating lesions of multiple sclerosis patients. Syncytin expression in astrocytes induced the release of redox reactants, which were cytotoxic to oligodendrocytes. Syncytin-mediated neuroinflammation and death of oligodendrocytes, with the ensuing neurobehavioral deficits, were prevented by the antioxidant ferulic acid in a mouse model of multiple sclerosis. Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention. |
| spellingShingle | Antony, J van Marle, G Opii, W Butterfield, D Mallet, F Yong, V Wallace, J Deacon, R Warren, K Power, C Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title_full | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title_fullStr | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title_full_unstemmed | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title_short | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. |
| title_sort | human endogenous retrovirus glycoprotein mediated induction of redox reactants causes oligodendrocyte death and demyelination |
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