Virus-directed, Enzyme Prodrug Therapy with Nitroimidazole Reductase: A Phase I and Pharmacokinetic Study of its Prodrug, CB1954

Virus-directed, Enzyme Prodrug Therapy with Nitroimidazole Reductase: A Phase I and Pharmacokinetic Study of its Prodrug, CB1954

<p style="text-align:justify;">CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent cytotoxic bifunctional alkylating agent, which can be delivered to tumors in adenoviral vectors as virus-directed, enzyme p...

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Bibliographic Details
Main Authors: Chung-Faye, G, Palmer, D, Anderson, D, Clark, J, Downes, M, Baddeley, J, Hussain, S, Murray, P, Searle, P, Seymour, L, Harris, P, Ferry, D, Kerr, D
Format: Journal article
Published: American Association for Cancer Research 2001

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