Expanding the malaria antibody toolkit: development and characterisation of Plasmodium falciparum RH5, CyRPA, and CSP recombinant human monoclonal antibodies

Expanding the malaria antibody toolkit: development and characterisation of Plasmodium falciparum RH5, CyRPA, and CSP recombinant human monoclonal antibodies

Malaria, an infection caused by apicomplexan parasites of the genus Plasmodium, continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in excess of 600,000. Considerable progress has been made to reduce malaria burden in endemic countries in...

書目詳細資料
Main Authors:	Nacer, A, Kivi, G, Pert, R, Juronen, E, Holenya, P, Aliprandini, E, Amino, R, Silvie, O, Quinkert, D, Le Duff, Y, Hurley, M, Reimer, U, Tover, A, Draper, SJ, Gilbert, S, Ho, MM, Bowyer, PW
格式:	Journal article
語言:	English
出版:	Frontiers Media 2022

相似書籍

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies
由: Adéla Nacer, et al.
出版: (2022-06-01)

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
由: Lin Chen, et al.
出版: (2017-02-01)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
由: Ragotte, RJ, et al.
出版: (2020)

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody
由: Paola Favuzza, et al.
出版: (2017-02-01)

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites
由: Knuepfer, E, et al.
出版: (2019)

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
由: Ellen Knuepfer, et al.
出版: (2019-06-01)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
由: Williams, BG, et al.
出版: (2024)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
由: Barnabas G. Williams, et al.
出版: (2024-06-01)

Bliss' and Loewe's additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations
由: Azasi, Y, et al.
出版: (2020)

Cysteine-Rich Protective Antigen (CyRPA) as promising blood-stage candidate protein for inclusion in a malaria subunit vaccine
由: Favuzza Paola, et al.
出版: (2012-10-01)

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
由: Healer, J, et al.
出版: (2022)

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
由: Julie Healer, et al.
出版: (2022-12-01)

Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)
由: Anjali Somanathan, et al.
出版: (2022-09-01)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites
由: Weiss, GE, et al.
出版: (2023)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
由: Greta E Weiss, et al.
出版: (2023-09-01)

Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of <i>Plasmodium vivax</i>: Follow-Up Study
由: Cinthia Magalhães Rodolphi, et al.
出版: (2024-08-01)

The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies
由: Ragotte, R
出版: (2020)

Low antibody titers against malaria vaccine candidates RH5, RIPR and CYRPA in naturally infected people in an endemic area of Mali
由: Draper, S, et al.
出版: (2018)

Signal stability of Cy3 and Cy5 on antibody microarrays
由: Kim Caroline, et al.
出版: (2006-10-01)

Leveraging Immunofocusing and Virus-like Particle Display to Enhance Antibody Responses to the Malaria Blood-Stage Invasion Complex Antigen PfCyRPA
由: Kasper H. Björnsson, et al.
出版: (2024-07-01)

The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
由: Christopher J. Day, et al.
出版: (2024-04-01)

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
由: Ragotte, RJ, et al.
出版: (2022)

The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
由: Marco Tamborrini, et al.
出版: (2023-07-01)

Sporozoite motility as a quantitative readout for anti-CSP antibody inhibition
由: C. M. de Korne, et al.
出版: (2022-10-01)

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
由: Manuela C. Aguirre-Botero, et al.
出版: (2023-07-01)

A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of <i>Plasmodium vivax</i> Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic <i>Plasmodium berghei</i> Parasite
由: Luciana C. Lima, et al.
出版: (2020-06-01)

Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities
由: Isabela Ferreira Soares, et al.
出版: (2024-11-01)

Using Cy5-dUTP labelling of RPA-amplicons with downstream microarray analysis for the detection of antibiotic resistance genes
由: Christian Warmt, et al.
出版: (2021-10-01)

Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody
由: Manuela C Aguirre-Botero, et al.
出版: (2025-02-01)

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies
由: Opeyemi Ernest Oludada, et al.
出版: (2023-04-01)

Immunogenicity of PvCyRPA, PvCelTOS and Pvs25 chimeric recombinant protein of Plasmodium vivax in murine model
由: Matos, ADS, et al.
出版: (2024)

Immunogenicity of PvCyRPA, PvCelTOS and Pvs25 chimeric recombinant protein of Plasmodium vivax in murine model
由: Ada da Silva Matos, et al.
出版: (2024-06-01)

Adeno‐associated viral vectored delivery of a monoclonal antibody gene against blood‐stage malaria
由: Bardelli, M, et al.
出版: (2019)

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies
由: Brandon K. Wilder, et al.
出版: (2022-05-01)

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
由: Robert J. Ragotte, et al.
出版: (2022-02-01)

Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
由: Bárbara Fernandes, et al.
出版: (2022-05-01)

Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
由: Mugo, RM, et al.
出版: (2021)

Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
由: Robert M. Mugo, et al.
出版: (2021-12-01)

Adeno-associated viral vectored delivery of a novel monoclonal antibody gene against blood-stage Plasmodium falciparum malaria
由: Bardelli, M, et al.
出版: (2018)

Microarray: Working with Cy3 and Cy5
由: Kristie Nybo
出版: (2013-09-01)