Genetics of type 2 diabetes.
Identification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of early 2007, the molecular basis of most forms of monogenic diabetes resulting from beta-cell dysfunction is known and, in particular, there has been rec...
| Huvudupphovsmän: | , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2007
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| _version_ | 1826264189455302656 |
|---|---|
| author | Owen, K McCarthy, M |
| author_facet | Owen, K McCarthy, M |
| author_sort | Owen, K |
| collection | OXFORD |
| description | Identification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of early 2007, the molecular basis of most forms of monogenic diabetes resulting from beta-cell dysfunction is known and, in particular, there has been recent success in delineating the genetic aetiology of neonatal diabetes. Finding genes predisposing to more common, multifactorial forms of type 2 diabetes represents a far greater challenge, and only a handful of robust, well-replicated examples have been established. Nevertheless, 2006 heralded identification of the most important type 2 diabetes susceptibility gene known so far, TCF7L2, and in 2007 large-scale genome-wide association studies are destined to provide novel insights into the genetic architecture and biology of type 2 diabetes. |
| first_indexed | 2024-03-06T20:03:45Z |
| format | Journal article |
| id | oxford-uuid:283935a6-4266-4c95-b7d1-62cae09f7723 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:03:45Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:283935a6-4266-4c95-b7d1-62cae09f77232022-03-26T12:11:34ZGenetics of type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:283935a6-4266-4c95-b7d1-62cae09f7723EnglishSymplectic Elements at Oxford2007Owen, KMcCarthy, MIdentification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of early 2007, the molecular basis of most forms of monogenic diabetes resulting from beta-cell dysfunction is known and, in particular, there has been recent success in delineating the genetic aetiology of neonatal diabetes. Finding genes predisposing to more common, multifactorial forms of type 2 diabetes represents a far greater challenge, and only a handful of robust, well-replicated examples have been established. Nevertheless, 2006 heralded identification of the most important type 2 diabetes susceptibility gene known so far, TCF7L2, and in 2007 large-scale genome-wide association studies are destined to provide novel insights into the genetic architecture and biology of type 2 diabetes. |
| spellingShingle | Owen, K McCarthy, M Genetics of type 2 diabetes. |
| title | Genetics of type 2 diabetes. |
| title_full | Genetics of type 2 diabetes. |
| title_fullStr | Genetics of type 2 diabetes. |
| title_full_unstemmed | Genetics of type 2 diabetes. |
| title_short | Genetics of type 2 diabetes. |
| title_sort | genetics of type 2 diabetes |
| work_keys_str_mv | AT owenk geneticsoftype2diabetes AT mccarthym geneticsoftype2diabetes |