Non-deletion haemoglobin H disease in Papua New Guinea.
Analysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. Study of restriction enzyme site and length polymorphisms and the use of oligonucleotide probes indicated that the mole...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1987
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| _version_ | 1826264200296529920 |
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| author | Hill, A Thein, S Mavo, B Weatherall, D Clegg, J |
| author_facet | Hill, A Thein, S Mavo, B Weatherall, D Clegg, J |
| author_sort | Hill, A |
| collection | OXFORD |
| description | Analysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. Study of restriction enzyme site and length polymorphisms and the use of oligonucleotide probes indicated that the molecular basis of this Papuan form of non-deletion Hb H disease differs from the previously described Middle Eastern and Mediterranean types. |
| first_indexed | 2024-03-06T20:03:57Z |
| format | Journal article |
| id | oxford-uuid:28489392-7eba-4811-85c4-ffd278fbaab8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:03:57Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:28489392-7eba-4811-85c4-ffd278fbaab82022-03-26T12:11:57ZNon-deletion haemoglobin H disease in Papua New Guinea.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:28489392-7eba-4811-85c4-ffd278fbaab8EnglishSymplectic Elements at Oxford1987Hill, AThein, SMavo, BWeatherall, DClegg, JAnalysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. Study of restriction enzyme site and length polymorphisms and the use of oligonucleotide probes indicated that the molecular basis of this Papuan form of non-deletion Hb H disease differs from the previously described Middle Eastern and Mediterranean types. |
| spellingShingle | Hill, A Thein, S Mavo, B Weatherall, D Clegg, J Non-deletion haemoglobin H disease in Papua New Guinea. |
| title | Non-deletion haemoglobin H disease in Papua New Guinea. |
| title_full | Non-deletion haemoglobin H disease in Papua New Guinea. |
| title_fullStr | Non-deletion haemoglobin H disease in Papua New Guinea. |
| title_full_unstemmed | Non-deletion haemoglobin H disease in Papua New Guinea. |
| title_short | Non-deletion haemoglobin H disease in Papua New Guinea. |
| title_sort | non deletion haemoglobin h disease in papua new guinea |
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