Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging.
The location of the human cortical substrate underlying simple horizontal saccadic eye movements was investigated using echoplanar functional magnetic resonance imaging (fMRI) in young healthy volunteers. Echoplanar imaging with signal targeting and alternating radiofrequency (EPISTAR), a novel perf...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| _version_ | 1797059431446347776 |
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| author | Darby, D Nobre, A Thangaraj, V Edelman, R Mesulam, M Warach, S |
| author_facet | Darby, D Nobre, A Thangaraj, V Edelman, R Mesulam, M Warach, S |
| author_sort | Darby, D |
| collection | OXFORD |
| description | The location of the human cortical substrate underlying simple horizontal saccadic eye movements was investigated using echoplanar functional magnetic resonance imaging (fMRI) in young healthy volunteers. Echoplanar imaging with signal targeting and alternating radiofrequency (EPISTAR), a novel perfusion technique, measured signal intensity changes in one to four contiguous 10-mm slices centered to include both striate cortex and putative frontal eye fields during horizontal saccade and fixation conditions. Subtraction images of self-paced visually guided saccadic versus fixation conditions showed bilateral marked and statistically significant localized signal increases in the precentral region (Brodmann areas 4, 6) and peristriate cortex (areas 17, 18, 19) and qualitative increases in the superior medial frontal region, as identified by a Talairach-Tournoux generalized template in the brain slices that were scanned. Additional parietal activation occurred during a target-guided saccade task. Our data (i) support the localization of the human FEF, as identified by simple, nonexploratory saccadic eye movements, in the precentral motor strip and premotor cortex, (ii) show individual variability in the exact anatomical location of saccade-related activations, and (iii) confirm that the EPISTAR technique can demonstrate localized signal increases during a behavioral task. |
| first_indexed | 2024-03-06T20:04:09Z |
| format | Journal article |
| id | oxford-uuid:2858414f-a1c8-47c4-a84e-f31506b8b668 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:04:09Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:2858414f-a1c8-47c4-a84e-f31506b8b6682022-03-26T12:12:26ZCortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2858414f-a1c8-47c4-a84e-f31506b8b668EnglishSymplectic Elements at Oxford1996Darby, DNobre, AThangaraj, VEdelman, RMesulam, MWarach, SThe location of the human cortical substrate underlying simple horizontal saccadic eye movements was investigated using echoplanar functional magnetic resonance imaging (fMRI) in young healthy volunteers. Echoplanar imaging with signal targeting and alternating radiofrequency (EPISTAR), a novel perfusion technique, measured signal intensity changes in one to four contiguous 10-mm slices centered to include both striate cortex and putative frontal eye fields during horizontal saccade and fixation conditions. Subtraction images of self-paced visually guided saccadic versus fixation conditions showed bilateral marked and statistically significant localized signal increases in the precentral region (Brodmann areas 4, 6) and peristriate cortex (areas 17, 18, 19) and qualitative increases in the superior medial frontal region, as identified by a Talairach-Tournoux generalized template in the brain slices that were scanned. Additional parietal activation occurred during a target-guided saccade task. Our data (i) support the localization of the human FEF, as identified by simple, nonexploratory saccadic eye movements, in the precentral motor strip and premotor cortex, (ii) show individual variability in the exact anatomical location of saccade-related activations, and (iii) confirm that the EPISTAR technique can demonstrate localized signal increases during a behavioral task. |
| spellingShingle | Darby, D Nobre, A Thangaraj, V Edelman, R Mesulam, M Warach, S Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title | Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title_full | Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title_fullStr | Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title_full_unstemmed | Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title_short | Cortical activation in the human brain during lateral saccades using EPISTAR functional magnetic resonance imaging. |
| title_sort | cortical activation in the human brain during lateral saccades using epistar functional magnetic resonance imaging |
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