Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing
<p>Core–shell superparamagnetic iron oxide nanoparticles hold great promise as a theranostic platform in biological systems. Herein, we report the biological effect of multifunctional cyclodextrin-appended SPIONs (CySPION) in mutant Npc1-deficient CHO cells compared to their wild type counterp...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
MDPI
2023
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| _version_ | 1826310277896863744 |
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| author | Puglisi, A Bognanni, N Vecchio, G Shepherd, D Platt, F |
| author_facet | Puglisi, A Bognanni, N Vecchio, G Shepherd, D Platt, F |
| author_sort | Puglisi, A |
| collection | OXFORD |
| description | <p>Core–shell superparamagnetic iron oxide nanoparticles hold great promise as a theranostic platform in biological systems. Herein, we report the biological effect of multifunctional cyclodextrin-appended SPIONs (CySPION) in mutant Npc1-deficient CHO cells compared to their wild type counterparts. CySPIONs show negligible cytotoxicity while they are strongly endocytosed and localized in the lysosomal compartment. Through their bespoke pH-sensitive chemistry, these nanoparticles release appended monomeric cyclodextrins to mobilize over-accumulated cholesterol and eject it outside the cells. CySPIONs show a high rate of transport across blood–brain barrier models, indicating their promise as a therapeutic approach for cholesterol-impaired diseases affecting the brain.</p> |
| first_indexed | 2024-03-07T07:49:35Z |
| format | Journal article |
| id | oxford-uuid:285c7ca0-2944-49d7-bbcd-ca8e8d16920d |
| institution | University of Oxford |
| last_indexed | 2024-03-07T07:49:35Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:285c7ca0-2944-49d7-bbcd-ca8e8d16920d2023-07-04T11:12:33ZGrafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:285c7ca0-2944-49d7-bbcd-ca8e8d16920dSymplectic ElementsMDPI2023Puglisi, ABognanni, NVecchio, GShepherd, DPlatt, F<p>Core–shell superparamagnetic iron oxide nanoparticles hold great promise as a theranostic platform in biological systems. Herein, we report the biological effect of multifunctional cyclodextrin-appended SPIONs (CySPION) in mutant Npc1-deficient CHO cells compared to their wild type counterparts. CySPIONs show negligible cytotoxicity while they are strongly endocytosed and localized in the lysosomal compartment. Through their bespoke pH-sensitive chemistry, these nanoparticles release appended monomeric cyclodextrins to mobilize over-accumulated cholesterol and eject it outside the cells. CySPIONs show a high rate of transport across blood–brain barrier models, indicating their promise as a therapeutic approach for cholesterol-impaired diseases affecting the brain.</p> |
| spellingShingle | Puglisi, A Bognanni, N Vecchio, G Shepherd, D Platt, F Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title | Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title_full | Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title_fullStr | Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title_full_unstemmed | Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title_short | Grafting of cyclodextrin to theranostic nanoparticles improves blood-brain barrier model crossing |
| title_sort | grafting of cyclodextrin to theranostic nanoparticles improves blood brain barrier model crossing |
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