Sources of retinal pigment epithelium (RPE) for replacement therapy.
Stem cells, with their capacity to regenerate and replace diseased tissues, have recently been proposed as having great potential in the treatment of age-related macular degeneration (AMD). A stem cell therapeutic approach could operate to replace either the retinal pigment epithelium (RPE), the neu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797059442170134528 |
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| author | Lee, E Maclaren, R |
| author_facet | Lee, E Maclaren, R |
| author_sort | Lee, E |
| collection | OXFORD |
| description | Stem cells, with their capacity to regenerate and replace diseased tissues, have recently been proposed as having great potential in the treatment of age-related macular degeneration (AMD). A stem cell therapeutic approach could operate to replace either the retinal pigment epithelium (RPE), the neurosensory retina or a combination of both. From the scientific perspective, RPE replacement alone is likely to be far more straightforward than rebuilding the complex circuitry of the neurosensory retina. Furthermore, recent advances with induced pluripotent stem cells have raised the real possibility of transplanting healthy 'young' autologous RPE into patients with early signs of AMD. At this stage, however, it is useful to reconsider some of the earlier clinical studies that used suspensions of autologous RPE cells harvested from the peripheral retina. These showed that isolated RPE cell suspensions had little capacity to recreate a monolayer on the diseased Bruch's membrane of AMD. To counter this problem, researchers from Southampton in the UK report the use of a synthetic polymer alternative to Bruch's membrane, which could provide a scaffold for future RPE derived from stem cells or possibly reopen opportunities for autologous RPE cells harvested from the peripheral retina. |
| first_indexed | 2024-03-06T20:04:19Z |
| format | Journal article |
| id | oxford-uuid:2869ce04-6b54-4dc4-8c7c-cc6165f20f78 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:04:19Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:2869ce04-6b54-4dc4-8c7c-cc6165f20f782022-03-26T12:12:43ZSources of retinal pigment epithelium (RPE) for replacement therapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2869ce04-6b54-4dc4-8c7c-cc6165f20f78EnglishSymplectic Elements at Oxford2011Lee, EMaclaren, RStem cells, with their capacity to regenerate and replace diseased tissues, have recently been proposed as having great potential in the treatment of age-related macular degeneration (AMD). A stem cell therapeutic approach could operate to replace either the retinal pigment epithelium (RPE), the neurosensory retina or a combination of both. From the scientific perspective, RPE replacement alone is likely to be far more straightforward than rebuilding the complex circuitry of the neurosensory retina. Furthermore, recent advances with induced pluripotent stem cells have raised the real possibility of transplanting healthy 'young' autologous RPE into patients with early signs of AMD. At this stage, however, it is useful to reconsider some of the earlier clinical studies that used suspensions of autologous RPE cells harvested from the peripheral retina. These showed that isolated RPE cell suspensions had little capacity to recreate a monolayer on the diseased Bruch's membrane of AMD. To counter this problem, researchers from Southampton in the UK report the use of a synthetic polymer alternative to Bruch's membrane, which could provide a scaffold for future RPE derived from stem cells or possibly reopen opportunities for autologous RPE cells harvested from the peripheral retina. |
| spellingShingle | Lee, E Maclaren, R Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title | Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title_full | Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title_fullStr | Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title_full_unstemmed | Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title_short | Sources of retinal pigment epithelium (RPE) for replacement therapy. |
| title_sort | sources of retinal pigment epithelium rpe for replacement therapy |
| work_keys_str_mv | AT leee sourcesofretinalpigmentepitheliumrpeforreplacementtherapy AT maclarenr sourcesofretinalpigmentepitheliumrpeforreplacementtherapy |