Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms
Employing predictions based on environmental regularities is fundamental for adaptive behaviour. While it is widely accepted that predictions across different stimulus attributes (e.g., time and content) facilitate sensory processing, it is unknown whether predictions across these attributes rely on...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
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Society for Neuroscience
2018
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| _version_ | 1797059445399748608 |
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| author | Auksztulewicz, R Schwiedrzik, C Thesen, T Doyle, W Devinsky, O Devinsky, O De Ozorio Nobre, A Schroeder, C Friston, K Melloni, L |
| author_facet | Auksztulewicz, R Schwiedrzik, C Thesen, T Doyle, W Devinsky, O Devinsky, O De Ozorio Nobre, A Schroeder, C Friston, K Melloni, L |
| author_sort | Auksztulewicz, R |
| collection | OXFORD |
| description | Employing predictions based on environmental regularities is fundamental for adaptive behaviour. While it is widely accepted that predictions across different stimulus attributes (e.g., time and content) facilitate sensory processing, it is unknown whether predictions across these attributes rely on the same neural mechanism. Here, to elucidate the neural mechanisms of predictions, we combine invasive electrophysiological recordings (human electrocorticography in 4 females and 2 males) with computational modelling while manipulating predictions about content (‘what’) and time (‘when’). We found that ‘when’ predictions increased evoked activity over motor and prefrontal regions both at early (∼180 ms) and late (430-450 ms) latencies. ‘What’ predictability, however, increased evoked activity only over prefrontal areas late in time (420-460 ms). Beyond these dissociable influences, we found that ‘what’ and ‘when’ predictability interactively modulated the amplitude of early (165 ms) evoked responses in the superior temporal gyrus. We modelled the observed neural responses using biophysically realistic neural mass models, to better understand whether ‘what’ and ‘when’ predictions tap into similar or different neurophysiological mechanisms. Our modelling results suggest that ‘what’ and ‘when’ predictability rely on complementary neural processes: ‘what’ predictions increased short-term plasticity in auditory areas, while ‘when’ predictability increased synaptic gain in motor areas. Thus, content and temporal predictions engage complementary neural mechanisms in different regions, suggesting domain-specific prediction signalling along the cortical hierarchy. Encoding predictions through different mechanisms may endow the brain with the flexibility to efficiently signal different sources of predictions, weight them by their reliability, and allow for their encoding without mutual interference. |
| first_indexed | 2024-03-06T20:04:22Z |
| format | Journal article |
| id | oxford-uuid:286d6988-a257-4fbb-bc6e-cf68b1bc7d7d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:04:22Z |
| publishDate | 2018 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | oxford-uuid:286d6988-a257-4fbb-bc6e-cf68b1bc7d7d2022-03-26T12:12:50ZNot all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanismsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:286d6988-a257-4fbb-bc6e-cf68b1bc7d7dSymplectic Elements at OxfordSociety for Neuroscience2018Auksztulewicz, RSchwiedrzik, CThesen, TDoyle, WDevinsky, ODevinsky, ODe Ozorio Nobre, ASchroeder, CFriston, KMelloni, LEmploying predictions based on environmental regularities is fundamental for adaptive behaviour. While it is widely accepted that predictions across different stimulus attributes (e.g., time and content) facilitate sensory processing, it is unknown whether predictions across these attributes rely on the same neural mechanism. Here, to elucidate the neural mechanisms of predictions, we combine invasive electrophysiological recordings (human electrocorticography in 4 females and 2 males) with computational modelling while manipulating predictions about content (‘what’) and time (‘when’). We found that ‘when’ predictions increased evoked activity over motor and prefrontal regions both at early (∼180 ms) and late (430-450 ms) latencies. ‘What’ predictability, however, increased evoked activity only over prefrontal areas late in time (420-460 ms). Beyond these dissociable influences, we found that ‘what’ and ‘when’ predictability interactively modulated the amplitude of early (165 ms) evoked responses in the superior temporal gyrus. We modelled the observed neural responses using biophysically realistic neural mass models, to better understand whether ‘what’ and ‘when’ predictions tap into similar or different neurophysiological mechanisms. Our modelling results suggest that ‘what’ and ‘when’ predictability rely on complementary neural processes: ‘what’ predictions increased short-term plasticity in auditory areas, while ‘when’ predictability increased synaptic gain in motor areas. Thus, content and temporal predictions engage complementary neural mechanisms in different regions, suggesting domain-specific prediction signalling along the cortical hierarchy. Encoding predictions through different mechanisms may endow the brain with the flexibility to efficiently signal different sources of predictions, weight them by their reliability, and allow for their encoding without mutual interference. |
| spellingShingle | Auksztulewicz, R Schwiedrzik, C Thesen, T Doyle, W Devinsky, O Devinsky, O De Ozorio Nobre, A Schroeder, C Friston, K Melloni, L Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title | Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title_full | Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title_fullStr | Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title_full_unstemmed | Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title_short | Not all predictions are equal: 'What' and 'When' predictions modulate activity in auditory cortex through different mechanisms |
| title_sort | not all predictions are equal what and when predictions modulate activity in auditory cortex through different mechanisms |
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