Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.

Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.

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BACKGROUND: Synthetic probes that mimic natural substrates can enable the detection of enzymatic activities in a cellular environment. One area where such activity-based probes have been applied is the ubiquitin-proteasome pathway, which is emerging as an important therapeutic target. A family of re...

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Príomhchruthaitheoirí:	Kramer, H, Nicholson, B, Kessler, B, Altun, M
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2012

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