RNA polymerase pausing during initial transcription

RNA polymerase pausing during initial transcription

In bacteria, RNA polymerase (RNAP) initiates transcription by synthesizing short transcripts that are either released or extended to allow RNAP to escape from the promoter. The mechanism of initial transcription is unclear due to the presence of transient intermediates and molecular heterogeneity. H...

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Manylion Llyfryddiaeth
Prif Awduron:	Duchi, D, Bauer, D, Fernandez, L, Evans, G, Robb, N, Hwang, L, Gryte, K, Tomescu, A, Zawadzki, P, Morichaud, Z, Brodolin, K, Kapanidis, A
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Cell Press 2016

Eitemau Tebyg

Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes
gan: Duchi, D, et al.
Cyhoeddwyd: (2017)

Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria
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The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: Implications for transcription start-site selection
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Cyhoeddwyd: (2013)

The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.
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Cyhoeddwyd: (2013)

Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria
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Cyhoeddwyd: (2018-04-01)

Single-Molecule Studies of Transcription Initiation using a Vesicle Approach
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CDK9-dependent RNA polymerase II pausing controls transcription initiation
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Cyhoeddwyd: (2017-10-01)

Real-time transcription initiation by E. coli RNA polymerase in vitro and in vivo
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Cyhoeddwyd: (2015)

RNA polymerase II pausing in development: orchestrating transcription
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Cyhoeddwyd: (2022-01-01)

Sensing DNA opening in transcription using quenchable Forster resonance energy transfer.
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Cyhoeddwyd: (2010)

A pause site for RNA polymerase II is associated with termination of transcription.
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Cyhoeddwyd: (1991)

Role of R-loops in pause-dependent transcriptional termination of RNA polymerase II
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Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
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Cyhoeddwyd: (2018-07-01)

Pause sites promote transcriptional termination of mammalian RNA polymerase II.
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Role of RNA Polymerase II Promoter-Proximal Pausing in Viral Transcription
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Cyhoeddwyd: (2022-09-01)

Characterizing Influenza a RNA Polymerase - Promoter Interaction using Ensemble Fluorescence Spectroscopy
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Cyhoeddwyd: (2013)

Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.
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Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism.
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Cyhoeddwyd: (2006)

Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
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Cyhoeddwyd: (2023-01-01)

Single-molecule studies of transcription initiation
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Cyhoeddwyd: (2014)

The RNA polymerase clamp interconverts dynamically among three states and is stabilized in a partly closed state by ppGpp
gan: Duchi, D, et al.
Cyhoeddwyd: (2018)

A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing
gan: Theophilus T. Tettey, et al.
Cyhoeddwyd: (2019-06-01)

A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis
gan: Adriana K. Alexander, et al.
Cyhoeddwyd: (2023-03-01)

The pause-initiation limit restricts transcription activation in human cells
gan: Saskia Gressel, et al.
Cyhoeddwyd: (2019-08-01)

Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing
gan: Wanqing Shao, et al.
Cyhoeddwyd: (2019-04-01)

The elemental mechanism of transcriptional pausing
gan: Jason Saba, et al.
Cyhoeddwyd: (2019-01-01)

Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.
gan: Eggermont, J, et al.
Cyhoeddwyd: (1993)

RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts.
gan: Krishanpal Anamika, et al.
Cyhoeddwyd: (2012-01-01)

Improved temporal resolution and linked hidden Markov modeling for switchable single-molecule FRET.
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Cyhoeddwyd: (2011)

Transcription Pause and Escape in Neurodevelopmental Disorders
gan: Kristel N. Eigenhuis, et al.
Cyhoeddwyd: (2022-05-01)

Tyrosine 1-phosphorylated RNA polymerase II transcribes PROMPTs to facilitate proximal promoter pausing and induce global transcriptional repression in response to DNA damage
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Cyhoeddwyd: (2024)

New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.
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Cyhoeddwyd: (1998)

Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability.
gan: Alistair N Boettiger, et al.
Cyhoeddwyd: (2011-05-01)

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
gan: Martell, DJ, et al.
Cyhoeddwyd: (2023)

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
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Grounded: Transcriptional Pausing in Naive mESCs
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Cyhoeddwyd: (2014)

YEAST RNA POLYMERASE-II TRANSCRIPTION - ENZYMATIC-ACTIVITIES OF GENERAL INITIATION-FACTORS, 3-D STRUCTURES OF INITIATION-FACTORS AND RNA-POLYMERASE, AND MECHANISM OF TRANSCRIPTIONAL ACTIVATION
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Structures of co-transcriptional RNA capping enzymes on paused transcription complex
gan: Yan Li, et al.
Cyhoeddwyd: (2024-05-01)

Definition of transcriptional pause elements in fission yeast.
gan: Aranda, A, et al.
Cyhoeddwyd: (1999)

c-Myc regulates transcriptional pause release
gan: Rahl, Peter B., et al.
Cyhoeddwyd: (2012)