The immunological synapse.
T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell-cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional dom...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797059478037725184 |
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| author | Dustin, M |
| author_facet | Dustin, M |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell-cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional domains: a central cluster of engaged antigen receptors and a surrounding ring of adhesion molecules. The segregation of the T-cell antigen receptor (TCR) and adhesion molecules is based on size, with the TCR interaction spanning 15 nm and the lymphocyte-function-associated antigen-1 (LFA-1) interaction spanning 30-40 nm between the two cells. Therefore, the synapse is not an empty gap, but a space populated by both adhesion and signaling molecules. This chapter considers four aspects of the immunological synapse: the role of migration and stop signals, the role of the cytoskeleton, the role of self-antigenic complexes, and the role of second signals. |
| first_indexed | 2024-03-06T20:04:48Z |
| format | Journal article |
| id | oxford-uuid:2890d9cf-0797-49ed-8e3e-b69f91969932 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:04:48Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:2890d9cf-0797-49ed-8e3e-b69f919699322022-03-26T12:13:38ZThe immunological synapse.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2890d9cf-0797-49ed-8e3e-b69f91969932EnglishSymplectic Elements at Oxford2002Dustin, MT-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell-cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional domains: a central cluster of engaged antigen receptors and a surrounding ring of adhesion molecules. The segregation of the T-cell antigen receptor (TCR) and adhesion molecules is based on size, with the TCR interaction spanning 15 nm and the lymphocyte-function-associated antigen-1 (LFA-1) interaction spanning 30-40 nm between the two cells. Therefore, the synapse is not an empty gap, but a space populated by both adhesion and signaling molecules. This chapter considers four aspects of the immunological synapse: the role of migration and stop signals, the role of the cytoskeleton, the role of self-antigenic complexes, and the role of second signals. |
| spellingShingle | Dustin, M The immunological synapse. |
| title | The immunological synapse. |
| title_full | The immunological synapse. |
| title_fullStr | The immunological synapse. |
| title_full_unstemmed | The immunological synapse. |
| title_short | The immunological synapse. |
| title_sort | immunological synapse |
| work_keys_str_mv | AT dustinm theimmunologicalsynapse AT dustinm immunologicalsynapse |