IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea.
Severe exercise in young females is a potent cause of menstrual irregularity, although the exact pathogenesis is currently unknown. We performed a cross-sectional endocrine and metabolic analysis of a group of elite athletes and dancers in order to establish which variable, if any, was specifically...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1826264275214139392 |
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| author | Jenkins, P Ibanez-Santos, X Holly, J Cotterill, A Perry, L Wolman, R Harries, M Grossman, A |
| author_facet | Jenkins, P Ibanez-Santos, X Holly, J Cotterill, A Perry, L Wolman, R Harries, M Grossman, A |
| author_sort | Jenkins, P |
| collection | OXFORD |
| description | Severe exercise in young females is a potent cause of menstrual irregularity, although the exact pathogenesis is currently unknown. We performed a cross-sectional endocrine and metabolic analysis of a group of elite athletes and dancers in order to establish which variable, if any, was specifically associated with changes in menstruation. By using a step-wise discriminant analysis, two independent predictors, elevated serum cortisol and insulin-like growth factor binding protein 1 (IGFBP-1) levels, were found to account for the majority (67%) of the variance. IGFBP-1 is a hepatic protein which is acutely and inversely regulated by insulin, and is thought to modulate the peripheral actions of IGF-1. While the change in serum cortisol may reflect activation of central stress pathways, these findings suggest for the first time that there is a second peripheral signal, IGFBP-1, which may relate the availability of metabolic fuels to the control of reproduction. |
| first_indexed | 2024-03-06T20:05:08Z |
| format | Journal article |
| id | oxford-uuid:28ab0f78-ad1d-4583-8d44-384d5208078c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:05:08Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:28ab0f78-ad1d-4583-8d44-384d5208078c2022-03-26T12:14:17ZIGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:28ab0f78-ad1d-4583-8d44-384d5208078cEnglishSymplectic Elements at Oxford1993Jenkins, PIbanez-Santos, XHolly, JCotterill, APerry, LWolman, RHarries, MGrossman, ASevere exercise in young females is a potent cause of menstrual irregularity, although the exact pathogenesis is currently unknown. We performed a cross-sectional endocrine and metabolic analysis of a group of elite athletes and dancers in order to establish which variable, if any, was specifically associated with changes in menstruation. By using a step-wise discriminant analysis, two independent predictors, elevated serum cortisol and insulin-like growth factor binding protein 1 (IGFBP-1) levels, were found to account for the majority (67%) of the variance. IGFBP-1 is a hepatic protein which is acutely and inversely regulated by insulin, and is thought to modulate the peripheral actions of IGF-1. While the change in serum cortisol may reflect activation of central stress pathways, these findings suggest for the first time that there is a second peripheral signal, IGFBP-1, which may relate the availability of metabolic fuels to the control of reproduction. |
| spellingShingle | Jenkins, P Ibanez-Santos, X Holly, J Cotterill, A Perry, L Wolman, R Harries, M Grossman, A IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title | IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title_full | IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title_fullStr | IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title_full_unstemmed | IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title_short | IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea. |
| title_sort | igfbp 1 a metabolic signal associated with exercise induced amenorrhoea |
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