Rapid formation of amyloid from alpha-monomeric recombinant human PrP in vitro.
The infectious agent of prion diseases is identified with PrP(Sc), a beta-rich, amyloidogenic and partially protease resistant isoform of the cellular glycoprotein, PrP(C). To understand the process of prion formation in vivo, we and others have studied defined misfolding pathways of recombinant PrP...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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