Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics
We numerically investigate the role of mechanical stress in modifying the conductivity properties of cardiac tissue, and also assess the impact of these effects in the solutions generated by computational models for cardiac electromechanics. We follow the recent theoretical framework from Cherubini...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Frontiers Media
2018
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| _version_ | 1826264308674199552 |
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| author | Loppini, A Gizzi, A Ruiz Baier, R Cherubini, C Fenton, F Filippi, S |
| author_facet | Loppini, A Gizzi, A Ruiz Baier, R Cherubini, C Fenton, F Filippi, S |
| author_sort | Loppini, A |
| collection | OXFORD |
| description | We numerically investigate the role of mechanical stress in modifying the conductivity properties of cardiac tissue, and also assess the impact of these effects in the solutions generated by computational models for cardiac electromechanics. We follow the recent theoretical framework from Cherubini et al. (2017), proposed in the context of general reaction-diffusion-mechanics systems emerging from multiphysics continuum mechanics and finite elasticity. In the present study, the adapted models are compared against preliminary experimental data of pig right ventricle fluorescence optical mapping. These data contribute to the characterization of the observed inhomogeneity and anisotropy properties that result from mechanical deformation. Our novel approach simultaneously incorporates two mechanisms for mechano-electric feedback (MEF): stretch-activated currents (SAC) and stress-assisted diffusion (SAD); and we also identify their influence into the nonlinear spatiotemporal dynamics. It is found that (i) only specific combinations of the two MEF effects allow proper conduction velocity measurement; (ii) expected heterogeneities and anisotropies are obtained via the novel stress-assisted diffusion mechanisms; (iii) spiral wave meandering and drifting is highly mediated by the applied mechanical loading. We provide an analysis of the intrinsic structure of the nonlinear coupling mechanisms using computational tests conducted with finite element methods. In particular, we compare static and dynamic deformation regimes in the onset of cardiac arrhythmias and address other potential biomedical applications. |
| first_indexed | 2024-03-06T20:05:42Z |
| format | Journal article |
| id | oxford-uuid:28d5e524-1411-4565-88f6-b6948f116011 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:05:42Z |
| publishDate | 2018 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:28d5e524-1411-4565-88f6-b6948f1160112022-03-26T12:15:25ZCompeting mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanicsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:28d5e524-1411-4565-88f6-b6948f116011Symplectic Elements at OxfordFrontiers Media2018Loppini, AGizzi, ARuiz Baier, RCherubini, CFenton, FFilippi, SWe numerically investigate the role of mechanical stress in modifying the conductivity properties of cardiac tissue, and also assess the impact of these effects in the solutions generated by computational models for cardiac electromechanics. We follow the recent theoretical framework from Cherubini et al. (2017), proposed in the context of general reaction-diffusion-mechanics systems emerging from multiphysics continuum mechanics and finite elasticity. In the present study, the adapted models are compared against preliminary experimental data of pig right ventricle fluorescence optical mapping. These data contribute to the characterization of the observed inhomogeneity and anisotropy properties that result from mechanical deformation. Our novel approach simultaneously incorporates two mechanisms for mechano-electric feedback (MEF): stretch-activated currents (SAC) and stress-assisted diffusion (SAD); and we also identify their influence into the nonlinear spatiotemporal dynamics. It is found that (i) only specific combinations of the two MEF effects allow proper conduction velocity measurement; (ii) expected heterogeneities and anisotropies are obtained via the novel stress-assisted diffusion mechanisms; (iii) spiral wave meandering and drifting is highly mediated by the applied mechanical loading. We provide an analysis of the intrinsic structure of the nonlinear coupling mechanisms using computational tests conducted with finite element methods. In particular, we compare static and dynamic deformation regimes in the onset of cardiac arrhythmias and address other potential biomedical applications. |
| spellingShingle | Loppini, A Gizzi, A Ruiz Baier, R Cherubini, C Fenton, F Filippi, S Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title | Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title_full | Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title_fullStr | Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title_full_unstemmed | Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title_short | Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics |
| title_sort | competing mechanisms of stress assisted diffusivity and stretch activated currents in cardiac electromechanics |
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