Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.
Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-...
| 主要な著者: | , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2010
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| _version_ | 1826264319325634560 |
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| author | Nozad Charoudeh, H Tang, Y Cheng, M Cilio, C Jacobsen, SE Sitnicka, E |
| author_facet | Nozad Charoudeh, H Tang, Y Cheng, M Cilio, C Jacobsen, SE Sitnicka, E |
| author_sort | Nozad Charoudeh, H |
| collection | OXFORD |
| description | Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. |
| first_indexed | 2024-03-06T20:05:53Z |
| format | Journal article |
| id | oxford-uuid:28e270cc-ad32-424c-bd25-9fe105424f74 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:05:53Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:28e270cc-ad32-424c-bd25-9fe105424f742022-03-26T12:15:43ZIdentification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:28e270cc-ad32-424c-bd25-9fe105424f74EnglishSymplectic Elements at Oxford2010Nozad Charoudeh, HTang, YCheng, MCilio, CJacobsen, SESitnicka, EAlthough bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. |
| spellingShingle | Nozad Charoudeh, H Tang, Y Cheng, M Cilio, C Jacobsen, SE Sitnicka, E Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title | Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title_full | Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title_fullStr | Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title_full_unstemmed | Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title_short | Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. |
| title_sort | identification of an nk t cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic dependent nk cells |
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