T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction
Infusion of in vitro–derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell–defi...
मुख्य लेखकों: | Smith, M, Reichenbach, D, Parker, S, Riddle, M, Mitchell, J, Osum, K, Mohtashami, M, Stefanski, H, Fife, B, Bhandoola, A, Hogquist, K, Holländer, G, Zúñiga-Pflücker, J, Tolar, J, Blazar, B |
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स्वरूप: | Journal article |
प्रकाशित: |
American Society for Clinical Investigatio
2017
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समान संसाधन
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The increase in thymopoiesis following T cell progenitor therapy is dependent upon the input population and continued interaction between developing T cells and the thymic microenvironment
द्वारा: Smith, M, और अन्य
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Thymic epithelial cell support of thymopoiesis does not require Klotho
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Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
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Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.
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Emerging strategies to boost thymic function.
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