13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans
Objective: Experimental studies have demonstrated that acute myocardial infarction (MI) alters energy metabolism even in non-infarcted adjacent tissue. In patients with subacute MI, the influence of the regional ischemic insult on energy metabolism of intact septal myocardium was analyzed using 31P-...
| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2001
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| _version_ | 1826264348320858112 |
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| author | Beer, M Buchner, S Sandstede, J Viehrig, M Lipke, C Krug, A Köstler, H Pabst, T Kenn, W Landschütz, W Von Kienlin, M Harre, K Neubauer, S Hahn, D |
| author_facet | Beer, M Buchner, S Sandstede, J Viehrig, M Lipke, C Krug, A Köstler, H Pabst, T Kenn, W Landschütz, W Von Kienlin, M Harre, K Neubauer, S Hahn, D |
| author_sort | Beer, M |
| collection | OXFORD |
| description | Objective: Experimental studies have demonstrated that acute myocardial infarction (MI) alters energy metabolism even in non-infarcted adjacent tissue. In patients with subacute MI, the influence of the regional ischemic insult on energy metabolism of intact septal myocardium was analyzed using 31P-Magnetic resonance spectroscopy (MRS). Patients and Methods: In eight patients with wall motion abnormalities in the anterior wall 31P-spectra were obtained from non-infarcted adjacent septal myocardium, as well as infarcted anterior myocardium (voxel size 25 ccm each) 29 ± 8 days after MI using a 3D-CSI technique. Additionally, cardiac function was analyzed using breath-hold cine MRI. MRI was repeated 6 months after revascularization to assess viability of infarcted segments. Eight age-matched healthy volunteers served as control group. Results: According to follow-up MRI 4/8 patients showed regional wall motion recovery. Here, PCr/ATP-ratios were not significantly reduced in intact septal myocardium as well as infarcted anterior myocardium compared to healthy volunteers (1.28 ± 0.10 and 1.14 ± 0.09 vs. 1.45 ± 0.29). No recovery of regional function was detected in 4/8 patients with - therefore - nonviable anterior myocardium. PCr/ATP-ratios were significantly reduced in intact and infarcted myocardium compared with healthy volunteers as well as to patients with wall motion recovery (0.77 ±0.17 and 0.49 ±0.23; P<0.05). Discussion: These preliminary results indicate that energy metabolism is reduced in patients with persisting wall motion abnormalities after myocardial infarction and revascularization in ischemically injured as well as in adjacent non-injured myocardium. © 2001 Elsevier Science B.V. All rights reserved. |
| first_indexed | 2024-03-06T20:06:21Z |
| format | Journal article |
| id | oxford-uuid:2907d0f6-7b6b-4c38-a0f8-6006d3dbf2f0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:06:21Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:2907d0f6-7b6b-4c38-a0f8-6006d3dbf2f02022-03-26T12:16:38Z 13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humansJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2907d0f6-7b6b-4c38-a0f8-6006d3dbf2f0EnglishSymplectic Elements at Oxford2001Beer, MBuchner, SSandstede, JViehrig, MLipke, CKrug, AKöstler, HPabst, TKenn, WLandschütz, WVon Kienlin, MHarre, KNeubauer, SHahn, DObjective: Experimental studies have demonstrated that acute myocardial infarction (MI) alters energy metabolism even in non-infarcted adjacent tissue. In patients with subacute MI, the influence of the regional ischemic insult on energy metabolism of intact septal myocardium was analyzed using 31P-Magnetic resonance spectroscopy (MRS). Patients and Methods: In eight patients with wall motion abnormalities in the anterior wall 31P-spectra were obtained from non-infarcted adjacent septal myocardium, as well as infarcted anterior myocardium (voxel size 25 ccm each) 29 ± 8 days after MI using a 3D-CSI technique. Additionally, cardiac function was analyzed using breath-hold cine MRI. MRI was repeated 6 months after revascularization to assess viability of infarcted segments. Eight age-matched healthy volunteers served as control group. Results: According to follow-up MRI 4/8 patients showed regional wall motion recovery. Here, PCr/ATP-ratios were not significantly reduced in intact septal myocardium as well as infarcted anterior myocardium compared to healthy volunteers (1.28 ± 0.10 and 1.14 ± 0.09 vs. 1.45 ± 0.29). No recovery of regional function was detected in 4/8 patients with - therefore - nonviable anterior myocardium. PCr/ATP-ratios were significantly reduced in intact and infarcted myocardium compared with healthy volunteers as well as to patients with wall motion recovery (0.77 ±0.17 and 0.49 ±0.23; P<0.05). Discussion: These preliminary results indicate that energy metabolism is reduced in patients with persisting wall motion abnormalities after myocardial infarction and revascularization in ischemically injured as well as in adjacent non-injured myocardium. © 2001 Elsevier Science B.V. All rights reserved. |
| spellingShingle | Beer, M Buchner, S Sandstede, J Viehrig, M Lipke, C Krug, A Köstler, H Pabst, T Kenn, W Landschütz, W Von Kienlin, M Harre, K Neubauer, S Hahn, D 13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title |
13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title_full |
13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title_fullStr |
13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title_full_unstemmed |
13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title_short |
13P-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
| title_sort | 13p mr spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans |
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