Multiscale topology characterises dynamic tumour vascular networks
Advances in imaging techniques enable high-resolution three-dimensional (3D) visualization of vascular networks over time and reveal abnormal structural features such as twists and loops, and their quantification is an active area of research. Here, we showcase how topological data analysis, the mat...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2022
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| _version_ | 1826307924406829056 |
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| author | Stolz-Pretzer, B Kaeppler, J Markelc, B Muschel, R Byrne, H Harrington, H |
| author_facet | Stolz-Pretzer, B Kaeppler, J Markelc, B Muschel, R Byrne, H Harrington, H |
| author_sort | Stolz-Pretzer, B |
| collection | OXFORD |
| description | Advances in imaging techniques enable high-resolution three-dimensional (3D) visualization of vascular networks over time and reveal abnormal structural features such as twists and loops, and their quantification is an active area of research. Here, we showcase how topological data analysis, the mathematical field that studies the “shape” of data, can characterize the geometric, spatial, and temporal organization of vascular networks. We propose two topological lenses to study vasculature, which capture inherent multiscale features and vessel connectivity, and surpass the single-scale analysis of existing methods. We analyze images collected using intravital and ultramicroscopy modalities and quantify spatiotemporal variation of twists, loops, and avascular regions (voids) in 3D vascular networks. This topological approach validates and quantifies known qualitative trends such as dynamic changes in tortuosity and loops in response to antibodies that modulate vessel sprouting; furthermore, it quantifies the effect of radiotherapy on vessel architecture. |
| first_indexed | 2024-03-07T07:10:22Z |
| format | Journal article |
| id | oxford-uuid:291cd01d-2df2-4f96-875a-37da28617a63 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:10:22Z |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:291cd01d-2df2-4f96-875a-37da28617a632022-06-24T14:15:34ZMultiscale topology characterises dynamic tumour vascular networksJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:291cd01d-2df2-4f96-875a-37da28617a63EnglishSymplectic ElementsAmerican Association for the Advancement of Science2022Stolz-Pretzer, BKaeppler, JMarkelc, BMuschel, RByrne, HHarrington, HAdvances in imaging techniques enable high-resolution three-dimensional (3D) visualization of vascular networks over time and reveal abnormal structural features such as twists and loops, and their quantification is an active area of research. Here, we showcase how topological data analysis, the mathematical field that studies the “shape” of data, can characterize the geometric, spatial, and temporal organization of vascular networks. We propose two topological lenses to study vasculature, which capture inherent multiscale features and vessel connectivity, and surpass the single-scale analysis of existing methods. We analyze images collected using intravital and ultramicroscopy modalities and quantify spatiotemporal variation of twists, loops, and avascular regions (voids) in 3D vascular networks. This topological approach validates and quantifies known qualitative trends such as dynamic changes in tortuosity and loops in response to antibodies that modulate vessel sprouting; furthermore, it quantifies the effect of radiotherapy on vessel architecture. |
| spellingShingle | Stolz-Pretzer, B Kaeppler, J Markelc, B Muschel, R Byrne, H Harrington, H Multiscale topology characterises dynamic tumour vascular networks |
| title | Multiscale topology characterises dynamic tumour vascular networks |
| title_full | Multiscale topology characterises dynamic tumour vascular networks |
| title_fullStr | Multiscale topology characterises dynamic tumour vascular networks |
| title_full_unstemmed | Multiscale topology characterises dynamic tumour vascular networks |
| title_short | Multiscale topology characterises dynamic tumour vascular networks |
| title_sort | multiscale topology characterises dynamic tumour vascular networks |
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