Posttransfusion Purpura
Posttransfusion purpura is an increasingly rare complication of blood transfusion. It is characterized by an acute episode of severe thrombocytopenia occurring about a week after a transfusion in HPA-1a negative women who have been alloimmunized by pregnancy. Although the thrombocytopenia resolves s...
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| Format: | Book section |
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John Wiley and Sons
2013
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| _version_ | 1826264386666233856 |
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| author | Murphy, M |
| author_facet | Murphy, M |
| author_sort | Murphy, M |
| collection | OXFORD |
| description | Posttransfusion purpura is an increasingly rare complication of blood transfusion. It is characterized by an acute episode of severe thrombocytopenia occurring about a week after a transfusion in HPA-1a negative women who have been alloimmunized by pregnancy. Although the thrombocytopenia resolves spontaneously within a few weeks, haemorrhage is common and sometimes severe. High-dose intravenous immunoglobulin (IVIgG) (2 g/kg given over 2 or 5 days) is the current treatment of choice to shorten the duration of thrombocytopenia, with responses in about 85% of cases. The pathophysiology remains uncertain. Universal leucocyte reduction of blood components in the UK has resulted in a marked reduction in the number of reported cases. This edition first published 2013 © 2001, 2005, 2009, 2013 John Wiley and Sons Ltd. |
| first_indexed | 2024-03-06T20:06:59Z |
| format | Book section |
| id | oxford-uuid:2933ea93-cf46-467e-b393-ec0082f70e0f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:06:59Z |
| publishDate | 2013 |
| publisher | John Wiley and Sons |
| record_format | dspace |
| spelling | oxford-uuid:2933ea93-cf46-467e-b393-ec0082f70e0f2022-03-26T12:17:47ZPosttransfusion PurpuraBook sectionhttp://purl.org/coar/resource_type/c_3248uuid:2933ea93-cf46-467e-b393-ec0082f70e0fSymplectic Elements at OxfordJohn Wiley and Sons2013Murphy, MPosttransfusion purpura is an increasingly rare complication of blood transfusion. It is characterized by an acute episode of severe thrombocytopenia occurring about a week after a transfusion in HPA-1a negative women who have been alloimmunized by pregnancy. Although the thrombocytopenia resolves spontaneously within a few weeks, haemorrhage is common and sometimes severe. High-dose intravenous immunoglobulin (IVIgG) (2 g/kg given over 2 or 5 days) is the current treatment of choice to shorten the duration of thrombocytopenia, with responses in about 85% of cases. The pathophysiology remains uncertain. Universal leucocyte reduction of blood components in the UK has resulted in a marked reduction in the number of reported cases. This edition first published 2013 © 2001, 2005, 2009, 2013 John Wiley and Sons Ltd. |
| spellingShingle | Murphy, M Posttransfusion Purpura |
| title | Posttransfusion Purpura |
| title_full | Posttransfusion Purpura |
| title_fullStr | Posttransfusion Purpura |
| title_full_unstemmed | Posttransfusion Purpura |
| title_short | Posttransfusion Purpura |
| title_sort | posttransfusion purpura |
| work_keys_str_mv | AT murphym posttransfusionpurpura |