Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats.
Rats were trained on a reinforced alternation paradigm using an elevated T-maze. After pre-surgical training subjects received either ibotenic acid (4 micrograms/0.4 microliter) or vehicle (pH 7.4, 0.4 microliter) bilaterally into the region of the nucleus basalis magnocellularis--an important sourc...
| Main Authors: | , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
1984
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| _version_ | 1826264391336591360 |
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| author | Salamone, J Beart, P Alpert, J Iversen, S |
| author_facet | Salamone, J Beart, P Alpert, J Iversen, S |
| author_sort | Salamone, J |
| collection | OXFORD |
| description | Rats were trained on a reinforced alternation paradigm using an elevated T-maze. After pre-surgical training subjects received either ibotenic acid (4 micrograms/0.4 microliter) or vehicle (pH 7.4, 0.4 microliter) bilaterally into the region of the nucleus basalis magnocellularis--an important source of neocortical acetylcholine projections. Acetylcholinesterase staining of sectioned brains revealed a loss of neocortical, but not hippocampal staining in lesioned animals. On the T-maze task, lesioned rats showed significantly impaired choice performance relative to controls. They also demonstrated significant side biases, the degree of which was correlated with choice performance deficit. |
| first_indexed | 2024-03-06T20:07:03Z |
| format | Journal article |
| id | oxford-uuid:293b07a7-51fb-435b-bf1d-2b7e3cb05ba4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:07:03Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:293b07a7-51fb-435b-bf1d-2b7e3cb05ba42022-03-26T12:18:00ZImpairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:293b07a7-51fb-435b-bf1d-2b7e3cb05ba4EnglishSymplectic Elements at Oxford1984Salamone, JBeart, PAlpert, JIversen, SRats were trained on a reinforced alternation paradigm using an elevated T-maze. After pre-surgical training subjects received either ibotenic acid (4 micrograms/0.4 microliter) or vehicle (pH 7.4, 0.4 microliter) bilaterally into the region of the nucleus basalis magnocellularis--an important source of neocortical acetylcholine projections. Acetylcholinesterase staining of sectioned brains revealed a loss of neocortical, but not hippocampal staining in lesioned animals. On the T-maze task, lesioned rats showed significantly impaired choice performance relative to controls. They also demonstrated significant side biases, the degree of which was correlated with choice performance deficit. |
| spellingShingle | Salamone, J Beart, P Alpert, J Iversen, S Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title | Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title_full | Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title_fullStr | Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title_full_unstemmed | Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title_short | Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats. |
| title_sort | impairment in t maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats |
| work_keys_str_mv | AT salamonej impairmentintmazereinforcedalternationperformancefollowingnucleusbasalismagnocellularislesionsinrats AT beartp impairmentintmazereinforcedalternationperformancefollowingnucleusbasalismagnocellularislesionsinrats AT alpertj impairmentintmazereinforcedalternationperformancefollowingnucleusbasalismagnocellularislesionsinrats AT iversens impairmentintmazereinforcedalternationperformancefollowingnucleusbasalismagnocellularislesionsinrats |