Targeting the viral Achilles' heel: Recognition of 5'-triphosphate RNA in innate anti-viral defence
Some RNA virus genomes bear 5'-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5'-triphosphate viral RNAs. RIG-I signals for induction...
| Autors principals: | , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2013
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