Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers
<p style="text-align:justify;"> <b>Background:</b> Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation fre...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 语言: | English |
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BioMed Central
2002
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| _version_ | 1826264412115173376 |
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| author | Jenkins, J Shajahan, P Lappin, J Ebmeier, K |
| author_facet | Jenkins, J Shajahan, P Lappin, J Ebmeier, K |
| author_sort | Jenkins, J |
| collection | OXFORD |
| description | <p style="text-align:justify;"> <b>Background:</b> Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation. <br/><br/> <b>Methods:</b> Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart.<br/><br/> <b>Results:</b> There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS.<br/><br/> <b>Conclusions:</b> Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood. </p> |
| first_indexed | 2024-03-06T20:07:22Z |
| format | Journal article |
| id | oxford-uuid:295a2f85-642f-48ee-871c-a1e95514e5e5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:07:22Z |
| publishDate | 2002 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:295a2f85-642f-48ee-871c-a1e95514e5e52022-03-26T12:18:38ZRight and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:295a2f85-642f-48ee-871c-a1e95514e5e5EnglishSymplectic Elements at OxfordBioMed Central2002Jenkins, JShajahan, PLappin, JEbmeier, K <p style="text-align:justify;"> <b>Background:</b> Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation. <br/><br/> <b>Methods:</b> Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart.<br/><br/> <b>Results:</b> There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS.<br/><br/> <b>Conclusions:</b> Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood. </p> |
| spellingShingle | Jenkins, J Shajahan, P Lappin, J Ebmeier, K Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_full | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_fullStr | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_full_unstemmed | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_short | Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers |
| title_sort | right and left prefrontal transcranial magnetic stimulation at 1 hz does not affect mood in healthy volunteers |
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