Virus-induced humoral immunity: On how B cell responses are initiated
Most antiviral vaccines are based on viral particles, which are efficient inducers of B cell responses. In addition to their ability to replicate, several features associated with the structure and content of the viral particles are responsible for this high immunogenicity. First, viral particles us...
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| Format: | Journal article |
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2013
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| _version_ | 1797059660176424960 |
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| author | Zabel, F Kündig, T Bachmann, M |
| author_facet | Zabel, F Kündig, T Bachmann, M |
| author_sort | Zabel, F |
| collection | OXFORD |
| description | Most antiviral vaccines are based on viral particles, which are efficient inducers of B cell responses. In addition to their ability to replicate, several features associated with the structure and content of the viral particles are responsible for this high immunogenicity. First, viral particles usually have dimensions between 20 and 200 nm, a size optimal for drainage to lymph nodes and direct interaction with B cells. Second, the surface of most viral particles is highly repetitive, causing efficient cross-linking of B cell receptors, an early and key step of B cell activation. In addition, such repetitive structures bind natural antibodies and fix complement, further enhancing B cell activation as well as transport to and deposition on follicular dendritic cells. Third, viral particles carry ligands for toll-like receptor 7/8 or 9 which activate B cells directly for isotype switching as well as dendritic cells for T cell priming. In this review, we will highlight recent insights in these mechanisms and discuss their impact on antiviral antibody responses. © 2013 Elsevier B.V. All rights reserved. |
| first_indexed | 2024-03-06T20:07:26Z |
| format | Journal article |
| id | oxford-uuid:29600a23-fe63-48e4-b3d6-8a1b98f7f2b5 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:07:26Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:29600a23-fe63-48e4-b3d6-8a1b98f7f2b52022-03-26T12:18:45ZVirus-induced humoral immunity: On how B cell responses are initiatedJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:29600a23-fe63-48e4-b3d6-8a1b98f7f2b5Symplectic Elements at Oxford2013Zabel, FKündig, TBachmann, MMost antiviral vaccines are based on viral particles, which are efficient inducers of B cell responses. In addition to their ability to replicate, several features associated with the structure and content of the viral particles are responsible for this high immunogenicity. First, viral particles usually have dimensions between 20 and 200 nm, a size optimal for drainage to lymph nodes and direct interaction with B cells. Second, the surface of most viral particles is highly repetitive, causing efficient cross-linking of B cell receptors, an early and key step of B cell activation. In addition, such repetitive structures bind natural antibodies and fix complement, further enhancing B cell activation as well as transport to and deposition on follicular dendritic cells. Third, viral particles carry ligands for toll-like receptor 7/8 or 9 which activate B cells directly for isotype switching as well as dendritic cells for T cell priming. In this review, we will highlight recent insights in these mechanisms and discuss their impact on antiviral antibody responses. © 2013 Elsevier B.V. All rights reserved. |
| spellingShingle | Zabel, F Kündig, T Bachmann, M Virus-induced humoral immunity: On how B cell responses are initiated |
| title | Virus-induced humoral immunity: On how B cell responses are initiated |
| title_full | Virus-induced humoral immunity: On how B cell responses are initiated |
| title_fullStr | Virus-induced humoral immunity: On how B cell responses are initiated |
| title_full_unstemmed | Virus-induced humoral immunity: On how B cell responses are initiated |
| title_short | Virus-induced humoral immunity: On how B cell responses are initiated |
| title_sort | virus induced humoral immunity on how b cell responses are initiated |
| work_keys_str_mv | AT zabelf virusinducedhumoralimmunityonhowbcellresponsesareinitiated AT kundigt virusinducedhumoralimmunityonhowbcellresponsesareinitiated AT bachmannm virusinducedhumoralimmunityonhowbcellresponsesareinitiated |