High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Bibliographic Details
Main Authors:	Stijlemans, B, Caljon, G, Natesan, S, Saerens, D, Conrath, K, Pérez-Morga, D, Skepper, J, Nikolaou, A, Brys, L, Pays, E, Magez, S, Field, M, De Baetselier, P, Muyldermans, S
Format:	Journal article
Language:	English
Published:	Public Library of Science 2011

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