Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).
CLEC-2 is a member of new family of C-type lectin receptors characterized by a cytosolic YXXL downstream of three acidic amino acids in a sequence known as a hemITAM (hemi-immunoreceptor tyrosine-based activation motif). Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the...
Հիմնական հեղինակներ: | Hughes, C, Sinha, U, Pandey, A, Eble, J, O'Callaghan, C, Watson, S |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2013
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