SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.

Programmed death-1 (PD-1) is a critical mediator of virus-specific CD8+ T-cell exhaustion. Here, we examined the expression of PD-1 on simian immunodeficiency virus (SIV)-specific CD8+ T cells and its possible involvement in regulation of cytokine production, proliferation, and survival of these cel...

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Bibliographic Details
Main Authors: Petrovas, C, Price, D, Mattapallil, J, Ambrozak, DR, Geldmacher, C, Cecchinato, V, Vaccari, M, Tryniszewska, E, Gostick, E, Roederer, M, Douek, D, Morgan, S, Davis, S, Franchini, G, Koup, R
Format: Journal article
Language:English
Published: 2007

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