Inflammatory biomarkers in Alzheimer's disease plasma
<p><strong>INTRODUCTION:</strong> Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers.</p> <p><strong>METHODS:</st...
| Päätekijät: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Elsevier
2019
|
| _version_ | 1826264437358592000 |
|---|---|
| author | Morgan, A Touchard, S Leckey, C O'Hagan, C Nevado-Holgado, A Nima Consortium Barkhof, F Bertram, L Blin, O Bos, I Dobricic, V Engelborghs, S Frisoni, G Frölich, L Gabel, S Johannsen, P Kettunen, P Kłoszewska, I Legido-Quigley, C Lleó, A Martinez-Lage, P Mecocci, P Meersmans, K Molinuevo, J Peyratout, G Popp, J Richardson, J Sala, I Scheltens, P Streffer, J Soininen, H Tainta-Cuezva, M Teunissen, C Tsolaki, M Vandenberghe, R Visser, P Vos, S Wahlund, L Wallin, A Westwood, S Zetterberg, H Lovestone, S Morgan, B |
| author_facet | Morgan, A Touchard, S Leckey, C O'Hagan, C Nevado-Holgado, A Nima Consortium Barkhof, F Bertram, L Blin, O Bos, I Dobricic, V Engelborghs, S Frisoni, G Frölich, L Gabel, S Johannsen, P Kettunen, P Kłoszewska, I Legido-Quigley, C Lleó, A Martinez-Lage, P Mecocci, P Meersmans, K Molinuevo, J Peyratout, G Popp, J Richardson, J Sala, I Scheltens, P Streffer, J Soininen, H Tainta-Cuezva, M Teunissen, C Tsolaki, M Vandenberghe, R Visser, P Vos, S Wahlund, L Wallin, A Westwood, S Zetterberg, H Lovestone, S Morgan, B |
| author_sort | Morgan, A |
| collection | OXFORD |
| description | <p><strong>INTRODUCTION:</strong> Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers.</p> <p><strong>METHODS:</strong> A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed.</p> <p><strong>RESULTS:</strong> Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71).</p> <p><strong>DISCUSSION:</strong> Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation.</p> |
| first_indexed | 2024-03-06T20:07:47Z |
| format | Journal article |
| id | oxford-uuid:297d858c-401e-4e5f-98b3-94b46c2d3531 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:07:47Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:297d858c-401e-4e5f-98b3-94b46c2d35312022-03-26T12:19:29ZInflammatory biomarkers in Alzheimer's disease plasmaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:297d858c-401e-4e5f-98b3-94b46c2d3531EnglishSymplectic Elements at OxfordElsevier2019Morgan, ATouchard, SLeckey, CO'Hagan, CNevado-Holgado, ANima ConsortiumBarkhof, FBertram, LBlin, OBos, IDobricic, VEngelborghs, SFrisoni, GFrölich, LGabel, SJohannsen, PKettunen, PKłoszewska, ILegido-Quigley, CLleó, AMartinez-Lage, PMecocci, PMeersmans, KMolinuevo, JPeyratout, GPopp, JRichardson, JSala, IScheltens, PStreffer, JSoininen, HTainta-Cuezva, MTeunissen, CTsolaki, MVandenberghe, RVisser, PVos, SWahlund, LWallin, AWestwood, SZetterberg, HLovestone, SMorgan, B<p><strong>INTRODUCTION:</strong> Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers.</p> <p><strong>METHODS:</strong> A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed.</p> <p><strong>RESULTS:</strong> Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71).</p> <p><strong>DISCUSSION:</strong> Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation.</p> |
| spellingShingle | Morgan, A Touchard, S Leckey, C O'Hagan, C Nevado-Holgado, A Nima Consortium Barkhof, F Bertram, L Blin, O Bos, I Dobricic, V Engelborghs, S Frisoni, G Frölich, L Gabel, S Johannsen, P Kettunen, P Kłoszewska, I Legido-Quigley, C Lleó, A Martinez-Lage, P Mecocci, P Meersmans, K Molinuevo, J Peyratout, G Popp, J Richardson, J Sala, I Scheltens, P Streffer, J Soininen, H Tainta-Cuezva, M Teunissen, C Tsolaki, M Vandenberghe, R Visser, P Vos, S Wahlund, L Wallin, A Westwood, S Zetterberg, H Lovestone, S Morgan, B Inflammatory biomarkers in Alzheimer's disease plasma |
| title | Inflammatory biomarkers in Alzheimer's disease plasma |
| title_full | Inflammatory biomarkers in Alzheimer's disease plasma |
| title_fullStr | Inflammatory biomarkers in Alzheimer's disease plasma |
| title_full_unstemmed | Inflammatory biomarkers in Alzheimer's disease plasma |
| title_short | Inflammatory biomarkers in Alzheimer's disease plasma |
| title_sort | inflammatory biomarkers in alzheimer s disease plasma |
| work_keys_str_mv | AT morgana inflammatorybiomarkersinalzheimersdiseaseplasma AT touchards inflammatorybiomarkersinalzheimersdiseaseplasma AT leckeyc inflammatorybiomarkersinalzheimersdiseaseplasma AT ohaganc inflammatorybiomarkersinalzheimersdiseaseplasma AT nevadoholgadoa inflammatorybiomarkersinalzheimersdiseaseplasma AT nimaconsortium inflammatorybiomarkersinalzheimersdiseaseplasma AT barkhoff inflammatorybiomarkersinalzheimersdiseaseplasma AT bertraml inflammatorybiomarkersinalzheimersdiseaseplasma AT blino inflammatorybiomarkersinalzheimersdiseaseplasma AT bosi inflammatorybiomarkersinalzheimersdiseaseplasma AT dobricicv inflammatorybiomarkersinalzheimersdiseaseplasma AT engelborghss inflammatorybiomarkersinalzheimersdiseaseplasma AT frisonig inflammatorybiomarkersinalzheimersdiseaseplasma AT frolichl inflammatorybiomarkersinalzheimersdiseaseplasma AT gabels inflammatorybiomarkersinalzheimersdiseaseplasma AT johannsenp inflammatorybiomarkersinalzheimersdiseaseplasma AT kettunenp inflammatorybiomarkersinalzheimersdiseaseplasma AT kłoszewskai inflammatorybiomarkersinalzheimersdiseaseplasma AT legidoquigleyc inflammatorybiomarkersinalzheimersdiseaseplasma AT lleoa inflammatorybiomarkersinalzheimersdiseaseplasma AT martinezlagep inflammatorybiomarkersinalzheimersdiseaseplasma AT mecoccip inflammatorybiomarkersinalzheimersdiseaseplasma AT meersmansk inflammatorybiomarkersinalzheimersdiseaseplasma AT molinuevoj inflammatorybiomarkersinalzheimersdiseaseplasma AT peyratoutg inflammatorybiomarkersinalzheimersdiseaseplasma AT poppj inflammatorybiomarkersinalzheimersdiseaseplasma AT richardsonj inflammatorybiomarkersinalzheimersdiseaseplasma AT salai inflammatorybiomarkersinalzheimersdiseaseplasma AT scheltensp inflammatorybiomarkersinalzheimersdiseaseplasma AT strefferj inflammatorybiomarkersinalzheimersdiseaseplasma AT soininenh inflammatorybiomarkersinalzheimersdiseaseplasma AT taintacuezvam inflammatorybiomarkersinalzheimersdiseaseplasma AT teunissenc inflammatorybiomarkersinalzheimersdiseaseplasma AT tsolakim inflammatorybiomarkersinalzheimersdiseaseplasma AT vandenbergher inflammatorybiomarkersinalzheimersdiseaseplasma AT visserp inflammatorybiomarkersinalzheimersdiseaseplasma AT voss inflammatorybiomarkersinalzheimersdiseaseplasma AT wahlundl inflammatorybiomarkersinalzheimersdiseaseplasma AT wallina inflammatorybiomarkersinalzheimersdiseaseplasma AT westwoods inflammatorybiomarkersinalzheimersdiseaseplasma AT zetterbergh inflammatorybiomarkersinalzheimersdiseaseplasma AT lovestones inflammatorybiomarkersinalzheimersdiseaseplasma AT morganb inflammatorybiomarkersinalzheimersdiseaseplasma |