Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition
Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of potent B1 MBL inhibitors. The inhibitors potentiate mer...
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Bibliographic Details
| Main Authors: |
Li, G,
Brem, J,
Lesniak, R,
Abboud, M,
Lohans, C,
Clifton, I,
Yang, S,
Jiménez-Castellanos, J,
Avison, M,
Spencer, J,
McDonough, M,
Schofield, C |
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| Format: | Journal article
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| Language: | English |
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| Published: |
Royal Society of Chemistry
2017
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