Biphenyl ether analogs containing pomalidomide as small-molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

Biphenyl ether analogs containing pomalidomide as small-molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

<p>New biphenyl-based chimeric compounds containing pomalidomide were developed and evaluated for their activity to inhibit and degrade the programmed cell death-1/programmed cell death- ligand 1 (PD-1/PD-L1) complex. Most of the compounds displayed excellent inhibitory activity against PD-1/P...

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Bibliographic Details
Main Authors: Shaabani, S, Gadina, L, Surmiak, E, Wang, Z, Zhang, B, Butera, R, Zarganis-Tzitzikas, T, Rodriguez, I, Kocik-Krol, J, Magiera-Mularz, K, Skalniak, L, Dömling, A, Holak, TA
Format: Journal article
Language:English
Published: MDPI 2022

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