Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a key role in the regulation of energy metabolism. In humans, mutations in the gamma2-subunit of AMPK cause cardiac hypertrophy associated with Wolff-Parkinson-White syndrome, characterized by vent...
Main Authors: | Davies, J, Wells, D, Liu, K, Whitrow, H, Daniel, T, Grignani, R, Lygate, C, Schneider, J, Noël, G, Watkins, H, Carling, D |
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Format: | Journal article |
Language: | English |
Published: |
2006
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