Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae).
Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymann...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1826264507561803776 |
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| author | Asano, N Nishida, M Miyauchi, M Ikeda, K Yamamoto, M Kizu, H Kameda, Y Watson, A Nash, R Fleet, G |
| author_facet | Asano, N Nishida, M Miyauchi, M Ikeda, K Yamamoto, M Kizu, H Kameda, Y Watson, A Nash, R Fleet, G |
| author_sort | Asano, N |
| collection | OXFORD |
| description | Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM). |
| first_indexed | 2024-03-06T20:08:56Z |
| format | Journal article |
| id | oxford-uuid:29e34ba3-17b3-43a9-ada3-a53f95dec776 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:08:56Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:29e34ba3-17b3-43a9-ada3-a53f95dec7762022-03-26T12:21:47ZPolyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:29e34ba3-17b3-43a9-ada3-a53f95dec776EnglishSymplectic Elements at Oxford2000Asano, NNishida, MMiyauchi, MIkeda, KYamamoto, MKizu, HKameda, YWatson, ANash, RFleet, GAdenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM). |
| spellingShingle | Asano, N Nishida, M Miyauchi, M Ikeda, K Yamamoto, M Kizu, H Kameda, Y Watson, A Nash, R Fleet, G Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title | Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title_full | Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title_fullStr | Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title_full_unstemmed | Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title_short | Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae). |
| title_sort | polyhydroxylated pyrrolidine and piperidine alkaloids from adenophora triphylla var japonica campanulaceae |
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