Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output.
Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, an...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1826264518140887040 |
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| author | Keene, A Stratmann, M Keller, A Perrat, P Vosshall, L Waddell, S |
| author_facet | Keene, A Stratmann, M Keller, A Perrat, P Vosshall, L Waddell, S |
| author_sort | Keene, A |
| collection | OXFORD |
| description | Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration. |
| first_indexed | 2024-03-06T20:09:07Z |
| format | Journal article |
| id | oxford-uuid:29f4bc20-206b-4ed3-b3ab-06e833517b6b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:09:07Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:29f4bc20-206b-4ed3-b3ab-06e833517b6b2022-03-26T12:22:08ZDiverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:29f4bc20-206b-4ed3-b3ab-06e833517b6bEnglishSymplectic Elements at Oxford2004Keene, AStratmann, MKeller, APerrat, PVosshall, LWaddell, SAmnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration. |
| spellingShingle | Keene, A Stratmann, M Keller, A Perrat, P Vosshall, L Waddell, S Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title | Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title_full | Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title_fullStr | Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title_full_unstemmed | Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title_short | Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. |
| title_sort | diverse odor conditioned memories require uniquely timed dorsal paired medial neuron output |
| work_keys_str_mv | AT keenea diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput AT stratmannm diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput AT kellera diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput AT perratp diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput AT vosshalll diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput AT waddells diverseodorconditionedmemoriesrequireuniquelytimeddorsalpairedmedialneuronoutput |