Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.

BACKGROUND: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison of Nef in vitro function has not been undertaken. Here, we investigate two of N...

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Bibliographic Details
Main Authors: Mann, J, Byakwaga, H, Kuang, X, Le, A, Brumme, C, Mwimanzi, P, Omarjee, S, Martin, E, Lee, G, Baraki, B, Danroth, R, McCloskey, R, Muzoora, C, Bangsberg, DR, Hunt, P, Goulder, P, Walker, B, Harrigan, P, Martin, J, Ndung'u, T, Brockman, M, Brumme, Z
Format: Journal article
Language:English
Published: Springer 2013

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