Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

BACKGROUND: Cohesin, a multisubunit protein complex conserved from yeast to humans, holds sister chromatids together from the onset of replication to their separation during anaphase. Cohesin consists of four core subunits, namely Smc1, Smc3, Scc1, and Scc3. Smc1 and Smc3 proteins are characterized...

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Príomhchruthaitheoirí:	Arumugam, P, Nishino, T, Haering, C, Gruber, S, Nasmyth, K
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2006

Míreanna comhchosúla

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.
de réir: Kudo, N, et al.
Foilsithe / Cruthaithe: (2009)

Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes
de réir: Aaron F Severson, et al.
Foilsithe / Cruthaithe: (2014-08-01)

Sister DNA entrapment between juxtaposed Smc heads and kleisin of the cohesin complex
de réir: Chapard, C, et al.
Foilsithe / Cruthaithe: (2019)

DNA passes through cohesin’s hinge as well as its Smc3–kleisin interface
de réir: James E Collier, et al.
Foilsithe / Cruthaithe: (2022-09-01)

Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1
de réir: Byung-Gil Lee, et al.
Foilsithe / Cruthaithe: (2016-03-01)

MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin
de réir: Zawadzka, K, et al.
Foilsithe / Cruthaithe: (2018)

MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin
de réir: Katarzyna Zawadzka, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis.
de réir: Eichinger, C, et al.
Foilsithe / Cruthaithe: (2013)

Cohesin: its roles and mechanisms.
de réir: Nasmyth, K, et al.
Foilsithe / Cruthaithe: (2009)

The cohesin ring concatenates sister DNA molecules.
de réir: Haering, C, et al.
Foilsithe / Cruthaithe: (2008)

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1
de réir: Maikel Castellano-Pozo, et al.
Foilsithe / Cruthaithe: (2023-08-01)

A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6
de réir: Lucie Vondrova, et al.
Foilsithe / Cruthaithe: (2020-06-01)

Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit
de réir: Shoji Tane, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Structure and function of cohesin's Scc3/SA regulatory subunit
de réir: Roig, M, et al.
Foilsithe / Cruthaithe: (2014)

The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering
de réir: Gamze Çamdere, et al.
Foilsithe / Cruthaithe: (2015-11-01)

Investigating the function and regulation of cohesin ATPase
de réir: Voulgaris, M
Foilsithe / Cruthaithe: (2021)

Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.
de réir: Gruber, S, et al.
Foilsithe / Cruthaithe: (2006)

A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex.
de réir: Ola Orgil, et al.
Foilsithe / Cruthaithe: (2015-03-01)

The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains
de réir: Marina Vitoria Gomes, et al.
Foilsithe / Cruthaithe: (2024-09-01)

Cohesin: a catenase with separate entry and exit gates?
de réir: Nasmyth, K
Foilsithe / Cruthaithe: (2011)

How Does Cohesin Hold Sister DNAs Together?
de réir: Nasmyth, K
Foilsithe / Cruthaithe: (2010)

How does cohesin hold sister DNAs together?
de réir: Nasmyth, K
Foilsithe / Cruthaithe: (2009)

The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU.
de réir: Sarah J Morgan, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Cohesin: Not Just Important in Mitosis!
de réir: Pauli, A, et al.
Foilsithe / Cruthaithe: (2010)

The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals
de réir: Farzana Tuli, et al.
Foilsithe / Cruthaithe: (2023-06-01)

MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
de réir: Martin Houlard, et al.
Foilsithe / Cruthaithe: (2021-12-01)

Scc2 is a potent activator of Cohesin’s ATPase that promotes loading by binding Scc1 without Pds5
de réir: Petela, N, et al.
Foilsithe / Cruthaithe: (2018)

Cohesin's concatenation of sister DNAs maintains their intertwining.
de réir: Farcas, A, et al.
Foilsithe / Cruthaithe: (2011)

Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development
de réir: Dongqing Mo, et al.
Foilsithe / Cruthaithe: (2020-07-01)

The mechanism by which chromosomal DNA molecules are held together: entrapment within cohesin rings?
de réir: Nasmyth, K
Foilsithe / Cruthaithe: (2015)

Identification of Functional Domains in the Cohesin Loader Subunit Scc4 by a Random Insertion/Dominant Negative Screen
de réir: Michal Shwartz, et al.
Foilsithe / Cruthaithe: (2016-08-01)

Both interaction surfaces within cohesin's hinge domain are essential for its stable chromosomal association.
de réir: Mishra, A, et al.
Foilsithe / Cruthaithe: (2010)

The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300
de réir: Dustin C. Becht, et al.
Foilsithe / Cruthaithe: (2024-04-01)

S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit
de réir: Karan Choudhary, et al.
Foilsithe / Cruthaithe: (2022-08-01)

Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers.
de réir: Ana M Valdeolmillos, et al.
Foilsithe / Cruthaithe: (2007-02-01)

Residues of helix ɑ2 are critical for catalytic efficiency of mycobacterial alkylhydroperoxide reductase subunit C
de réir: Chong, Shi Min Sherilyn, et al.
Foilsithe / Cruthaithe: (2021)

Structure of a novel winged-helix like domain from human NFRKB protein.
de réir: Abhinav Kumar, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.
de réir: Oliveira, R, et al.
Foilsithe / Cruthaithe: (2010)

Cohesin Loss Eliminates All Loop Domains
de réir: Rao, Suhas S.P., et al.
Foilsithe / Cruthaithe: (2018)

Scc2/Nipbl hops between chromosomal cohesin rings after loading.
de réir: Rhodes, J, et al.
Foilsithe / Cruthaithe: (2017)