The malarial fever response--pathogenesis, polymorphism and prospects for intervention.
It is estimated that over 200 million people each year suffer debilitating attacks of malarial fever, and roughly 2 million of these episodes are fatal. The fever is caused by tumour necrosis factor (TNF) and other pyrogenic cytokines that are released by the host immune system response to products...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826264527699705856 |
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| author | Kwiatkowski, D Bate, C Scragg, I Beattie, P Udalova, I Knight, J |
| author_facet | Kwiatkowski, D Bate, C Scragg, I Beattie, P Udalova, I Knight, J |
| author_sort | Kwiatkowski, D |
| collection | OXFORD |
| description | It is estimated that over 200 million people each year suffer debilitating attacks of malarial fever, and roughly 2 million of these episodes are fatal. The fever is caused by tumour necrosis factor (TNF) and other pyrogenic cytokines that are released by the host immune system response to products of schizont rupture. TNF has anti-parasitic properties but excessive TNF production is thought to play an important role in the pathogenesis of cerebral malaria. This review summarizes recent attempts to achieve molecular characterization of the parasite components that stimulate the host TNF response, and to define the host and parasite factors that affect the level of TNF production. Of particular interest are host polymorphisms that may regulate TNF gene expression, and naturally acquired antibodies that prevent the parasite from inducing TNF, both of which correlate with the clinical severity of infection. Our understanding of these processes, which are potentially of considerable therapeutic relevance, remains very limited at both the molecular and the epidemiological level. |
| first_indexed | 2024-03-06T20:09:16Z |
| format | Journal article |
| id | oxford-uuid:2a029a99-a97c-415e-b93a-b3caa6c44a2e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:09:16Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:2a029a99-a97c-415e-b93a-b3caa6c44a2e2022-03-26T12:22:23ZThe malarial fever response--pathogenesis, polymorphism and prospects for intervention.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2a029a99-a97c-415e-b93a-b3caa6c44a2eEnglishSymplectic Elements at Oxford1997Kwiatkowski, DBate, CScragg, IBeattie, PUdalova, IKnight, JIt is estimated that over 200 million people each year suffer debilitating attacks of malarial fever, and roughly 2 million of these episodes are fatal. The fever is caused by tumour necrosis factor (TNF) and other pyrogenic cytokines that are released by the host immune system response to products of schizont rupture. TNF has anti-parasitic properties but excessive TNF production is thought to play an important role in the pathogenesis of cerebral malaria. This review summarizes recent attempts to achieve molecular characterization of the parasite components that stimulate the host TNF response, and to define the host and parasite factors that affect the level of TNF production. Of particular interest are host polymorphisms that may regulate TNF gene expression, and naturally acquired antibodies that prevent the parasite from inducing TNF, both of which correlate with the clinical severity of infection. Our understanding of these processes, which are potentially of considerable therapeutic relevance, remains very limited at both the molecular and the epidemiological level. |
| spellingShingle | Kwiatkowski, D Bate, C Scragg, I Beattie, P Udalova, I Knight, J The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title | The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title_full | The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title_fullStr | The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title_full_unstemmed | The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title_short | The malarial fever response--pathogenesis, polymorphism and prospects for intervention. |
| title_sort | malarial fever response pathogenesis polymorphism and prospects for intervention |
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