NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 mus...

Full description

Bibliographic Details
Main Authors:	Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications, Ltd 2016

Similar Items

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors
by: Dalei Wu, et al.
Published: (2016-10-01)

Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
by: David C Bersten, et al.
Published: (2014-01-01)

Structural characterization of mammalian bHLH-PAS transcription factors
by: Wu, D, et al.
Published: (2016)

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex
by: Diao, X, et al.
Published: (2025)

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex
by: Xiaotong Diao, et al.
Published: (2025-02-01)

NPAs in India's banks: trends and determinants
by: Santosh Kumar Das
Published: (2023-12-01)

BANKS’ PROFITABILITY AND NPAs: AN EMPIRICAL STUDY
by: Ms. Astha Dewan, et al.
Published: (2016-07-01)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.
by: MacDonald, P, et al.
Published: (2011)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion
by: MacDonald, P, et al.
Published: (2011)

Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders
by: Joseph J. Rossi, et al.
Published: (2021-03-01)

Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics.
by: Stefano Motta, et al.
Published: (2018-02-01)

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells.
by: Wood, S, et al.
Published: (1996)

The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories.
by: Jonathan E Ploski, et al.
Published: (2011-01-01)

Npas4: Linking Neuronal Activity to Memory
by: Sun, Xiaochen, et al.
Published: (2017)

De Kalkarse beeldhouwer Arnt van Tricht
by: G. de Werd
Published: (1973-06-01)

NPAs and profitability in Indian banks: an empirical analysis
by: Santosh Kumar Das, et al.
Published: (2021-11-01)

PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation
by: Gunsmaa Nyamsuren, et al.
Published: (2021-12-01)

Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing
by: Yoichiro Shibuya, et al.
Published: (2022-01-01)

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression
by: Anto Sam Crosslee Louis Sam Titus, et al.
Published: (2019-12-01)

De pendant van Arnt van Trichts Johannesbeeld
by: G. de Werd
Published: (1980-09-01)

NPAS4L is involved in avian hemangioblast specification
by: Wei Weng, et al.
Published: (2020-02-01)

Structural insights and characterization of human Npas4 protein
by: Ammad Fahim, et al.
Published: (2018-06-01)

The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor
by: Rashad Haidar, et al.
Published: (2021-09-01)

bHLH and bHLH-LZ factor exchange at promoters
by: Louphrasitthiphol, P
Published: (2015)

Npas4-mediated dopaminergic regulation of safety memory consolidation
by: BumJin Ko, et al.
Published: (2023-07-01)

Decreased Npas4 expression in patients with post-stroke depression
by: Shina Gu, et al.
Published: (2019-06-01)

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
by: Dominic Landgraf, et al.
Published: (2016-02-01)

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
by: Angela R. Ozburn, et al.
Published: (2017-11-01)

Two bHLH transcription factors, bHLH48 and bHLH60, associate with phytochrome interacting factor 7 to regulate hypocotyl elongation in Arabidopsis
by: Chuanwei Yang, et al.
Published: (2021-05-01)

Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
by: Pecenova L., et al.
Published: (2016-07-01)

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation
by: Ramamoorthi, Kartik, et al.
Published: (2014)

Identification and Functional Characterization of the Transcription Factors AhR/ARNT in <i>Dendroctonus armandi</i>
by: Bin Liu, et al.
Published: (2022-11-01)

Activity-dependent expression of neuronal PAS domain-containing 1 protein 4 (npas4a) in the developing zebrafish brain
by: Thomas eKlaric, et al.
Published: (2014-12-01)

ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy
by: Jiye Choi, et al.
Published: (2024-09-01)

Npas4 Expression in Two Experimental Models of the Barrel Cortex Plasticity
by: Aleksandra Kaliszewska, et al.
Published: (2015-01-01)

Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology
by: Emanuele Murgo, et al.
Published: (2023-10-01)

The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.
by: Dan Wang, et al.
Published: (2014-01-01)

NPAS2 and PER2 are linked to risk factors of the metabolic syndrome
by: Aromaa Arpo, et al.
Published: (2009-05-01)

Beta-cell ARNT is required for normal glucose tolerance in murine pregnancy.
by: Sue Mei Lau, et al.
Published: (2013-01-01)

bHLH003, bHLH013 and bHLH017 are new targets of JAZ repressors negatively regulating JA responses.
by: Sandra Fonseca, et al.
Published: (2014-01-01)