Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back
GABAergic interneurones are necessary for the emergence of hippocampal gamma-frequency network oscillations, during which they play a key role in the synchronization of pyramidal cell firing. However, it remains to be resolved how distinct interneurone subtypes contribute to gamma-frequency oscillat...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797059813773934592 |
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| author | Mann, E Radcliffe, C Paulsen, O |
| author_facet | Mann, E Radcliffe, C Paulsen, O |
| author_sort | Mann, E |
| collection | OXFORD |
| description | GABAergic interneurones are necessary for the emergence of hippocampal gamma-frequency network oscillations, during which they play a key role in the synchronization of pyramidal cell firing. However, it remains to be resolved how distinct interneurone subtypes contribute to gamma-frequency oscillations, in what way the spatiotemporal pattern of interneuronal input affects principal cell activity; and by which mechanisms the interneurones themselves are synchronized. Here we summarize recent evidence from cholinergically induced gamma-frequency network oscillations in vitro, showing that perisomatic-targeting GABAergic interneurones provide prominent rhythmic inhibition in pyramidal cells, and that these interneurones are synchronized by recurrent excitation. We conclude by presenting a minimal integrate-and-fire network model which demonstrates that this excitatory-inhibitory feedback loop is sufficient to explain the generation of intrahippocampal gamma-frequency oscillations. © The Physiological Society 2004. |
| first_indexed | 2024-03-06T20:09:28Z |
| format | Journal article |
| id | oxford-uuid:2a12e160-20d6-4726-aa52-8c0b737b3560 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:09:28Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:2a12e160-20d6-4726-aa52-8c0b737b35602022-03-26T12:22:53ZHippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and backJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2a12e160-20d6-4726-aa52-8c0b737b3560EnglishSymplectic Elements at Oxford2005Mann, ERadcliffe, CPaulsen, OGABAergic interneurones are necessary for the emergence of hippocampal gamma-frequency network oscillations, during which they play a key role in the synchronization of pyramidal cell firing. However, it remains to be resolved how distinct interneurone subtypes contribute to gamma-frequency oscillations, in what way the spatiotemporal pattern of interneuronal input affects principal cell activity; and by which mechanisms the interneurones themselves are synchronized. Here we summarize recent evidence from cholinergically induced gamma-frequency network oscillations in vitro, showing that perisomatic-targeting GABAergic interneurones provide prominent rhythmic inhibition in pyramidal cells, and that these interneurones are synchronized by recurrent excitation. We conclude by presenting a minimal integrate-and-fire network model which demonstrates that this excitatory-inhibitory feedback loop is sufficient to explain the generation of intrahippocampal gamma-frequency oscillations. © The Physiological Society 2004. |
| spellingShingle | Mann, E Radcliffe, C Paulsen, O Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title | Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title_full | Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title_fullStr | Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title_full_unstemmed | Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title_short | Hippocampal gamma-frequency oscillations: From interneurones to pyramidal cells, and back |
| title_sort | hippocampal gamma frequency oscillations from interneurones to pyramidal cells and back |
| work_keys_str_mv | AT manne hippocampalgammafrequencyoscillationsfrominterneuronestopyramidalcellsandback AT radcliffec hippocampalgammafrequencyoscillationsfrominterneuronestopyramidalcellsandback AT paulseno hippocampalgammafrequencyoscillationsfrominterneuronestopyramidalcellsandback |