Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive H3K27me3 epigenetic marks are catalyzed by polycom...

書誌詳細
主要な著者:	Barthlott, T, Handel, AE, Teh, HY, Wirasinha, RC, Hafen, K, Zuklys, S, Roch, B, Orkin, SH, de Villartay, J-P, Daley, SR, Holländer, GA
フォーマット:	Journal article
言語:	English
出版事項:	Springer Nature 2021

類似資料

TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
著者:: Hauri-Hohl, M, 等
出版事項: (2008)

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
著者:: Hauri-Hohl, M, 等
出版事項: (2008)

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
著者:: Žuklys, S, 等
出版事項: (2016)

Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
著者:: Žuklys, S, 等
出版事項: (2016)

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
著者:: Jeker, LT, 等
出版事項: (2008)

Delta-like 4 is indispensable in thymic environment specific for T cell development.
著者:: Hozumi, K, 等
出版事項: (2008)

Thymic epithelial organoids mediate T-cell development
著者:: Hübscher, T, 等
出版事項: (2024)

Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development
著者:: Handel, A, 等
出版事項: (2018)

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
著者:: Zuklys, S, 等
出版事項: (2009)

Transcriptional and epigenetic mechanisms of promiscuous gene expression by thymic epithelial cells
著者:: Dhalla, F
出版事項: (2019)

Comment on "Identification of an intronic regulatory element necessary for tissue-specific expression of Foxn1 in thymic epithelial cells"
著者:: Handel, AE, 等
出版事項: (2019)

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
著者:: Kanhere, Aditi, 等
出版事項: (2015)

Thymus extracellular matrix-derived scaffolds support graft-resident thymopoiesis and long-term in vitro culture of adult thymic epithelial cells
著者:: Asnaghi, MA, 等
出版事項: (2021)

The molecular determinants of Polycomb-mediated gene repression
著者:: Fursova, N
出版事項: (2019)

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.
著者:: Ohigashi, I, 等
出版事項: (2013)

Thymic epithelial cell support of thymopoiesis does not require Klotho
著者:: Xing, Y, 等
出版事項: (2018)

Sonic Hedgehog regulates thymic epithelial cell differentiation
著者:: Saldana, J, 等
出版事項: (2016)

The molecular principles of gene regulation by Polycomb repressive complexes
著者:: Blackledge, NP, 等
出版事項: (2021)

The role of thymic tolerance in CNS autoimmune disease
著者:: Handel, A, 等
出版事項: (2018)

The role of thymic tolerance in CNS autoimmune disease
著者:: Handel, A, 等
出版事項: (2018)

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
著者:: Jenkinson, SR, 等
出版事項: (2013)

Spatial (Tbata) expression in mature medullary thymic epithelial cells.
著者:: Saade, M, 等
出版事項: (2010)

LENTIVIRAL TRANSDUCTION OF PRIMARY ADULT MOUSE THYMIC EPITHELIAL CELLS TO CREATE CELLS COMPETENT TO SUPPORT REGULAR THYMOPOIESIS BOTH IN VITRO AND IN VIVO
著者:: Bosticardo, M, 等
出版事項: (2012)

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
著者:: Papadopoulou, A, 等
出版事項: (2012)

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.
著者:: Shitara, S, 等
出版事項: (2013)

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
著者:: Rossi, S, 等
出版事項: (2007)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.
著者:: Hauri-Hohl, M, 等
出版事項: (2014)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
著者:: Hauri-Hohl, M, 等
出版事項: (2014)

Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
著者:: Wendland, K, 等
出版事項: (2018)

AB009. Spatial proteomic analysis of the human thymic microenvironment shaping T cell development
著者:: Hanna, KS, 等
出版事項: (2023)

Characterisation of AEBP2: a polycomb repressive complex 2 component
著者:: Grijzenhout, A
出版事項: (2013)

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
著者:: Vroegindeweij, E, 等
出版事項: (2010)

A Polycomb-based switch underlying quantitative epigenetic memory.
著者:: Angel, A, 等
出版事項: (2011)

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes
著者:: King, H, 等
出版事項: (2018)

The immunopathology of thymic GVHD.
著者:: Krenger, W, 等
出版事項: (2008)

Lentiviral Vector-Mediated Induction of Oct4 Expression in Primary Adult Mouse Thymic Epithelial Cells To Generate Tools for Gene Replacement and Tissue Regeneration
著者:: Bosticardo, M, 等
出版事項: (2014)

The role of Polycomb-mediated epigenetic regulation in embryonic stem cell differentiation
著者:: Thornton, Seraphim R
出版事項: (2014)

Requirement of stat3 signaling in the postnatal development of thymic medullary epithelial cells
著者:: Satoh, R, 等
出版事項: (2016)

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
著者:: Dhalla, F, 等
出版事項: (2019)

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.
著者:: Sansom, S, 等
出版事項: (2014)