Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line.

Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line.

BACKGROUND/AIM: The mode of action of the somatostatin analog octreotide on neuro-endocrine tumour proliferation is largely unknown. Overexpression of the proto-oncogene Akt/PKB (protein kinase B) has been demonstrated in certain neuro-endocrine tumours: Akt activates downstream proteins including...

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Bibliographic Details
Main Authors:	Grozinsky-Glasberg, S, Franchi, G, Teng, M, Leontiou, C, Ribeiro de Oliveira, A, Dalino, P, Salahuddin, N, Korbonits, M, Grossman, AB
Format:	Journal article
Language:	English
Published:	2008

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