Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts
Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We in...
Հիմնական հեղինակներ: | Wright, PT, Bhogal, NK, Diakonov, I, Pannell, LMK, Perera, RK, Bork, NI, Schobesberger, S, Lucarelli, C, Faggian, G, Alvarez-Laviada, A, Zaccolo, M, Kamp, TJ, Balijepalli, RC, Lyon, AR, Harding, SE, Nikolaev, VO, Gorelik, J |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
Elsevier
2018
|
Նմանատիպ նյութեր
-
Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts
: Peter T. Wright, և այլն
Հրապարակվել է: (2018-04-01) -
Phosphodiesterases and compartmentalized cAMP signalling in the heart.
: Zaccolo, M
Հրապարակվել է: (2006) -
Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
: Koschinski, A, և այլն
Հրապարակվել է: (2017) -
Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.
: Stangherlin, A, և այլն
Հրապարակվել է: (2012) -
Role of membrane microdomains in compartmentation of cAMP signaling.
: Shailesh R Agarwal, և այլն
Հրապարակվել է: (2014-01-01)