Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We in...

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Những tác giả chính:	Wright, PT, Bhogal, NK, Diakonov, I, Pannell, LMK, Perera, RK, Bork, NI, Schobesberger, S, Lucarelli, C, Faggian, G, Alvarez-Laviada, A, Zaccolo, M, Kamp, TJ, Balijepalli, RC, Lyon, AR, Harding, SE, Nikolaev, VO, Gorelik, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Elsevier 2018

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