Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We in...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Wright, PT, Bhogal, NK, Diakonov, I, Pannell, LMK, Perera, RK, Bork, NI, Schobesberger, S, Lucarelli, C, Faggian, G, Alvarez-Laviada, A, Zaccolo, M, Kamp, TJ, Balijepalli, RC, Lyon, AR, Harding, SE, Nikolaev, VO, Gorelik, J
स्वरूप: Journal article
भाषा:English
प्रकाशित: Elsevier 2018

समान संसाधन