Asymmetric remote C-H functionalization: use of internal olefins in tandem hydrometallation-isomerization-asymmetric conjugate addition sequences

Asymmetric remote C-H functionalization: use of internal olefins in tandem hydrometallation-isomerization-asymmetric conjugate addition sequences

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We describe catalytic asymmetric C-C formation using terminal alkyl-metal nucleophiles generated from internal olefins through a 'chain-walking' isomerization mechanism. Hydrometallation of internal olefins with the Schwartz reagent gives the least hindered alkyl-zirconocene after thermal...

书目详细资料
Main Authors:	Mola, L, Sidera, M, Fletcher, S
格式:	Journal article
出版:	CSIRO Publishing 2015

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