Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey
<p><strong>Background</strong></p> <p>Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remai...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1797059898274480128 |
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| author | Chevance, A Ravaud, P Tomlinson, A Le Berre, C Teufer, B Touboul, S Fried, EI Gartlehner, G Cipriani, A Tran, VT |
| author_facet | Chevance, A Ravaud, P Tomlinson, A Le Berre, C Teufer, B Touboul, S Fried, EI Gartlehner, G Cipriani, A Tran, VT |
| author_sort | Chevance, A |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
<p>Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear.</p>
<p><strong>Methods</strong></p>
<p>We did an international online survey in French, German, and English. Participants were adult patients with a history of depression, informal caregivers, and health-care professionals, recruited by purposeful sampling. To identify outcome domains, participants answered four open-ended questions about their expectations for depression treatment. We disseminated the survey without restriction via social media, patient and professional associations, and a media campaign. Four researchers independently did qualitative content analyses. We assessed data saturation using mathematical models to ensure the comprehensive identification of outcome domains.</p>
<p><strong>Findings</strong></p>
<p>Between April 5, 2018, and Dec 10, 2018, 1912 patients, 464 informal caregivers, and 627 health-care professionals from 52 countries provided 8183 open-ended answers. We identified 80 outcome domains related to symptoms (64 domains), such as mental pain (or psychological or psychic pain, 523 [17%] of 3003 participants) and motivation (384 [13%]), and functioning (16 domains), such as social isolation (541 [18%]). We identified 57 other outcome domains regarding safety of treatment, health care organisation, and social representation, such as stigmatisation (408 [14%]).</p>
<p><strong>Interpretation</strong></p>
<p>This study provides a list of outcome domains important to patients, informal caregivers, and health-care professionals. Unfortunately, many of these domains are rarely measured in clinical trials. Results from this study should set the foundation for a core outcome set for depression.</p>
<p><strong>Funding</strong></p>
<p>Fondation pour la Recherche Medicale and NIHR Oxford Health Biomedical Research Centre.</p> |
| first_indexed | 2024-03-06T20:10:35Z |
| format | Journal article |
| id | oxford-uuid:2a6d0e66-a16b-4712-9a53-01fba140248a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:10:35Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:2a6d0e66-a16b-4712-9a53-01fba140248a2022-03-26T12:25:02ZIdentifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online surveyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2a6d0e66-a16b-4712-9a53-01fba140248aEnglishSymplectic ElementsElsevier2020Chevance, ARavaud, PTomlinson, ALe Berre, C Teufer, BTouboul, SFried, EIGartlehner, GCipriani, ATran, VT<p><strong>Background</strong></p> <p>Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear.</p> <p><strong>Methods</strong></p> <p>We did an international online survey in French, German, and English. Participants were adult patients with a history of depression, informal caregivers, and health-care professionals, recruited by purposeful sampling. To identify outcome domains, participants answered four open-ended questions about their expectations for depression treatment. We disseminated the survey without restriction via social media, patient and professional associations, and a media campaign. Four researchers independently did qualitative content analyses. We assessed data saturation using mathematical models to ensure the comprehensive identification of outcome domains.</p> <p><strong>Findings</strong></p> <p>Between April 5, 2018, and Dec 10, 2018, 1912 patients, 464 informal caregivers, and 627 health-care professionals from 52 countries provided 8183 open-ended answers. We identified 80 outcome domains related to symptoms (64 domains), such as mental pain (or psychological or psychic pain, 523 [17%] of 3003 participants) and motivation (384 [13%]), and functioning (16 domains), such as social isolation (541 [18%]). We identified 57 other outcome domains regarding safety of treatment, health care organisation, and social representation, such as stigmatisation (408 [14%]).</p> <p><strong>Interpretation</strong></p> <p>This study provides a list of outcome domains important to patients, informal caregivers, and health-care professionals. Unfortunately, many of these domains are rarely measured in clinical trials. Results from this study should set the foundation for a core outcome set for depression.</p> <p><strong>Funding</strong></p> <p>Fondation pour la Recherche Medicale and NIHR Oxford Health Biomedical Research Centre.</p> |
| spellingShingle | Chevance, A Ravaud, P Tomlinson, A Le Berre, C Teufer, B Touboul, S Fried, EI Gartlehner, G Cipriani, A Tran, VT Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title | Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title_full | Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title_fullStr | Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title_full_unstemmed | Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title_short | Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey |
| title_sort | identifying outcomes for depression that matter to patients informal caregivers and health care professionals qualitative content analysis of a large international online survey |
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