A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer.

A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer.

PURPOSE: Preclinical and clinical studies have demonstrated that inhibition of prenylation can radiosensitize cell lines with activation of Ras and produce clinical response in patients with cancer. The aim of this study was to determine the maximally tolerated dose of the dual farnesyltransferase...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Martin, N, Brunner, T, Kiel, K, DeLaney, T, Regine, W, Mohiuddin, M, Rosato, E, Haller, D, Stevenson, J, Smith, D, Pramanik, B, Tepper, J, Tanaka, W, Morrison, B, Deutsch, P, Gupta, A, Muschel, R, Mckenna, W, Bernhard, E, Hahn, S
التنسيق: Journal article
اللغة:English
منشور في: 2004

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